Six New 9,19-Cycloartane Triterpenoids from Cimicifuga foetida L.

Six new 9,19-cycloartane triterpene derivatives, as well as 3 known analogues (7-9), were isolated from the roots of Cimicifuga foetida L. Their structures were established on the basis of extensive spectroscopic analyses (IR, UV, ORD, HRESIMS, 1D and 2D NMR).

Cycloartane Glycosides from the Roots of with Wnt Signaling Pathway Inhibitory Activity.

Four new 9,19-cycloartane triterpenoids, cimilactone E (), cimilactone F (), 2'--()-butenoyl-23--26-deoxyactein (), and 2',12--diacetylcimiracemonol-3---d-xylopyranoside (), together with four known constituents (-) were isolated from the roots of . The new structures were elucidated by extensive spectroscopic analysis. In addition, compounds and showed significant Wnt signaling pathway inhibitory activity, with IC values of 3.

New 9, 19-cycloartane triterpenoid from the root of Cimicifuga foetida.

Aim: To study the 9, 19-cycloartane triterpenes from the roots of Cimicifuga foetida.

Method: Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography (HPLC) were used. All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods.