Identification of Immune and Hypoxia Risk Classifier to Estimate Immune Microenvironment and Prognosis in Cervical Cancer.

Purpose: Cervical cancer (CC) is one of the most common gynecologic neoplasms. Hypoxia is an essential trigger for activating immunosuppressive activity and initiating malignant tumors. However, the determination of the role of immunity and hypoxia on the clinical outcome of CC patients remains unclear.

Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization.

Vascular restenosis is the main factor affecting the prognosis of angioplasty in cardiovascular diseases, and inflammation is a central link in the progression of restenosis. Previous research that applies interleukin 10 (IL10) nanoparticles can effectively regulate local inflammation, but their targeted delivery efficacy remains to be improved. In this study, IL10 nanoparticles were successfully prepared and then coated by a preactive platelet membrane.

Novel Cu-based immobilized metal affinity magnetic nanoparticles for fast magnetic solid-phase extraction of trace Sudan dyes in food samples.

A novel type of Cu-based immobilized metal affinity magnetic nanoparticles (MHNTs@PDA@Cu) was designed and synthesized by a facile and green strategy, and served as an adsorbent for magnetic solid-phase extraction (MSPE) of trace Sudan dyes in foodstuffs. Owing to π-π stacking, hydrogen bonding, hydrophobic and Cu-azo coordination, MHNTs@PDA@Cu possesses superior affinity and very fast adsorption capability to Sudan dyes (adsorption time of 1 min). The main parameters influencing the extraction efficiency of MSPE were investigated and optimized.

An ultra-performance LC-MS/MS method for determination of JRF103 in human plasma: application in first in-patient study.

JRF103, a novel pan-HER inhibitor, has shown potent activity against HER1, HER2, HER4 and EGFR . To support its first in-patient trial, a sensitive and rapid method was developed and validated using ultra-performance LC-MS/MS. JRF103 was extracted from plasma using protein precipitation.

A bio-inspired, ultra-tough, high-sensitivity, and anti-swelling conductive hydrogel strain sensor for motion detection and information transmission.

Conductive hydrogels are excellent candidates for the next-generation wearable materials and are being extensively investigated for their potential use in health monitoring devices, human-machine interfaces, and other fields. However, their relatively low mechanical strength and performance degradation due to swelling have presented challenges in their practical application. Inspired by the multiscale heterogeneous architecture of biological tissue, a dynamic cross-linked, ultra-tough, and high-sensitivity hydrogel with a swelling resistance characteristic was fabricated by the principle of multiple non-covalent interaction matching and a step-by-step construction strategy.

YAP/Smad3 promotes pathological extracellular matrix microenviroment-induced bladder smooth muscle proliferation in bladder fibrosis progression.

Fibrosis is a chronic inflammation process with excess extracellular matrix (ECM) deposition that cannot be reversed. Patients suffer from bladder dysfunction caused by bladder fibrosis. Moreover, the interactive mechanisms between ECM and bladder fibrosis are still obscure.

Hexagonal boron nitride nanosheets based magnetic solid phase extraction for the extraction of phenoxy carboxylic acid herbicides from water samples followed by high-performance liquid chromatography-tandem mass spectrometry.

High-efficiency caption of pesticide residue is of vital significance for environmental safety monitoring. Herein, a hexagonal boron nitride nanosheets-based magnetic composite (FeO@h-BNNSs) was synthesized and applied for the magnetic solid phase extraction (MSPE) of five phenoxy carboxylic acid (PCA) herbicides from water samples. Based on the π-π interaction, hydrogen bond and halogen bond, the FeO@h-BNNSs composite showed excellent adsorption ability towards PCA herbicides.

An Image Encryption Algorithm Based on Complex Network Scrambling and Multi-Directional Diffusion.

Various security threats are encountered when keys are transmitted in public channels. In this paper, we propose an image encryption algorithm based on complex network scrambling and multi-directional diffusion. Combining the idea of public key cryptography, the RSA algorithm is used to encrypt the key related to plaintext.

Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults: The FIT-AGEING study.

Introduction: Vitamin D - concretely its active form 1,25-dihydroxyvitamin D (1,25(OH)D) - maintains several physiological processes. Oxylipins are oxidized lipids derived from ω-6 and ω-3 polyunsaturated fatty acids involved in inflammation. Little is known about the association of 1,25(OH)D with inflammatory parameters in middle-aged populations - who could be at risk of vitamin D deficiency -.

[Smoking relapse rate and influencing factors in smokers aged 15 years and above in China].

To describe the relapse status of smokers aged ≥15 years in China, and investigate the main factors influencing their relapse behavior. The data of this study cames from the 2018 China Adult Tobacco Survey, covering 400 committees or villages in 200 districts or counties in 31 provinces (autonomous regions and municipalities) of China. The relevant data of smoking and relapsing in residents aged ≥15 years were collected by face-to-face interview.

Selenium distribution, translocation and speciation in wheat (Triticum aestivum L.) after foliar spraying selenite and selenate.

Given the wide-spread consumption of wheat, the production of selenium (Se)-enriched wheat grain may be an effective method to increase the dietary Se intake in many Se-deficient areas. Herein, we biofortified wheat (Triticum aestivum L.) via the foliar spraying of selenate or selenite at low or high rate, and investigated the resulting Se distribution in different wheat parts and the crucial parts involved in grain Se accumulation.

Effect of steam explosion on nutritional components, physicochemical and rheological properties of brown rice powder.

Brown rice powder is underutilized mainly due to its lower starch digestibility and poor processing performance. The present study investigated the potential of steam explosion on the improvement of nutritional and physicochemical characteristic in brown rice powder and rheological property of paste. Compared with native brown rice powder, steam explosion at 0.

Association between prenatal antibiotics exposure and measures of fetal growth: A repeated-measure study.

The abuse of antibiotics in animal husbandry has brought many public health problems, among which the passive use of antibiotics caused by eating food containing residual antibiotics has attracted the most attention. However, few studies have examined the possible adverse effects of prenatal antibiotics exposure on fetal growth and development. In this study, we investigated the associations between prenatal antibiotics exposure and measures of fetal growth.

Quantitative interactome proteomics identifies a proteostasis network for GABA receptors.

Gamma-aminobutyric acid type A (GABA) receptors are the primary inhibitory neurotransmitter-gated ion channels in the mammalian central nervous system. Maintenance of GABA receptor protein homeostasis (proteostasis) in cells utilizing its interacting proteins is essential for the function of GABA receptors. However, how the proteostasis network orchestrates GABA receptor biogenesis in the endoplasmic reticulum is not well understood.

Exploiting Dynamic Nonlinearity in Upconversion Nanoparticles for Super-Resolution Imaging.

Single-beam super-resolution microscopy, also known as superlinear microscopy, exploits the nonlinear response of fluorescent probes in confocal microscopy. The technique requires no complex purpose-built system, light field modulation, or beam shaping. Here, we present a strategy to enhance this technique's spatial resolution by modulating excitation intensity during image acquisition.

Irradiation induces DJ-1 secretion from esophageal squamous cell carcinoma cells to accelerate metastasis of bystander cells via a TGF-β1 positive feedback loop.

Background: Radiation-induced bystander effect (RIBE) can promote tumor metastasis contributing to the failure of radiotherapy for esophageal squamous cell carcinoma (ESCC). Aberrant expression of DJ-1 has been identified in ESCC; however, the relationship between DJ-1 and RIBE in ESCC remains unknown.

Methods: We detected DJ-1 in the serum and cell supernatants by enzyme-linked immunosorbent assay (ELISA) and evaluated tumor metastasis by phenotypic experiments in vivo and in vitro.

A rare case report of multifocal para-aortic and para-vesical paragangliomas.

Background: Paragangliomas (PGLs) are uncommon tumors of uncertain malignant potential. Multifocal paragangliomas are scarcely reported in the literature.

Case Summary: A 25-year-old male patient was reported for the first time with multifocal para-aortic and para-vesical PGLs.

Rationale and design for the study of recombinant human hepatocyte growth factor plasmid in the treatment of patients with chronic limb-threatening ischemia (HOPE CLTI): Randomized, placebo-controlled, double-blind, phase III clinical trials.

Background: Although patients with CLTI have benefited from the rapid development of endovascular techniques, many patients are considered unsuitable for revascularization procedures. A previous phase II clinical trial has suggested that recombinant human hepatocyte growth factor plasmid (NL003) can salvage limbs during the treatment of patients with CLTI. However, the safety and efficacy of this drug need to be evaluated in a larger cohort.

Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma.

Alternative RNA splicing is one of the most important mechanisms of posttranscriptional gene regulation, which contributes to protein diversity in eukaryotes. It is well known that RNA splicing dysregulation is a critical mechanism in tumor pathogenesis and the rationale for the promising splice-switching therapeutics for cancer treatment. Although we have a comprehensive understanding of DNA mutations, abnormal gene expression profiles, epigenomics, and proteomics in lung adenocarcinoma (LUAD), little is known about its aberrant alternative splicing profiles.

Case report: I seed implantation for rare malignant solitary fibrous tumor in the pelvic cavity: a case report.

Solitary fibrous tumor (SFT) is a rare spindle cell tumor, benign or low-grade malignant, with an extremely low possibility of occurrence of malignant solitary fibrous tumor (MSFT). Surgery is an effective way for treating SFT, but it is often difficult to resect completely due to a large size, with a high recurrence rate and mortality rate after operation. Additionally, SFT is relatively resistant to chemotherapy, and there is a lack of effective systemic drug treatment.

Lanthanide Ion Resonance-Driven Rayleigh Scattering of Nanoparticles for Dual-Modality Interferometric Scattering Microscopy.

Light scattering from nanoparticles is significant in nanoscale imaging, photon confinement. and biosensing. However, engineering the scattering spectrum, traditionally by modifying the geometric feature of particles, requires synthesis and fabrication with nanometre accuracy.

Prognostic factors for 495 nonoperative esophageal squamous cancer patients receiving IMRT plus chemotherapy: A retrospective analysis.

Purpose: Chemoradiotherapy is regarded as a standard scheme for inoperable and unresectable esophageal cancers. Our aims were to explore the prognostic factors relevant to esophageal squamous cell carcinoma (ESCC) following intensity-modulated radiation therapy (IMRT) plus chemotherapy.

Material And Methods: Totally 495 ESCC patients undergoing IMRT combined with chemotherapy in our hospital between 2011 and 2020 were retrospectively analyzed.

Simultaneous determination and pharmacokinetics study of valsartan, sacubitril and its major metabolite in human plasma, urine and peritoneal dialysis fluid in patients with end-stage renal disease by UPLC-MS/MS.

Sacubitril/valsartan was indicated for the treatment of heart failure and hypertension in patients with end-stage renal disease on peritoneal dialysis therapy. Herein, a rapid, sensitive and robust method based on ultra-liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed and validated for the determination of the concentrations of valsartan, sacubitril and its major metabolite LBQ657 in plasma, urine and peritoneal dialysis fluid. Samples were extracted from various biological fluids using protein precipitation.

Prevalence, frequency, intensity, and location of cigarette use among adolescents in China from 2013-14 to 2019: Findings from two repeated cross-sectional studies.

Background: The burden of disease caused by tobacco use is a grave public health concern in China. Preventing smoking initiation among adolescents will lower the prevalence of adult tobacco use later. Surveillance of tobacco use among adolescents helps set priorities in developing tobacco control policies.

An Encryption Algorithm for Region of Interest in Medical DICOM Based on One-Dimensional -cos-cot Map.

Today, with the rapid development of the Internet, improving image security becomes more and more important. To improve image encryption efficiency, a novel region of interest (ROI) encryption algorithm based on a chaotic system was proposed. First, a new 1D eλ-cos-cot (1D-ECC) with better chaotic performance than the traditional chaotic system is proposed.