Evaluating the impacts of drilling and extraction activities on the marine carbonate system in the natural gas fields of Beibu Gulf, Northern South China Sea.

Natural gas fields are typically located in shallow gulfs. Previous studies have predominantly focused on gas leakage and its subsequent toxic effects on marine organisms; however, the impacts of accidental CO leaks on carbonate dynamics during drilling and extraction remain poorly understood. In this study, we investigate carbonate parameters in two gas fields to elucidate the influences of extraction activities and natural processes on carbonate dynamics in Beibu Gulf, situated in the northern South China Sea (nSCS).

Unexpected ice-edge diatom blooms occur as thin phytoplankton layers in Barrow Canyon, Chukchi Sea.

Observations of environmental variables and photosynthetic pigments were carried out in and around Barrow Canyon, northeast Chukchi Sea, from 2008 to 2016. Barrow Canyon and its western flank are occupied by relatively cold waters (T < 0 °C) with high nutrient and chlorophyll concentrations, whereas the eastern flank is occupied by relatively warm waters (T > 0 °C) with low nutrient and chlorophyll concentrations. The variable dominance of these cold and warm waters appears to be the main driving factor of regional differences in phytoplankton distribution in and around Barrow Canyon.

The Impact of Job Resources on Job Satisfaction, Emotion, and Psychological Health Among Social Workers in China.

Social work is a caring profession, as social workers are required to provide psychological support and emotional caring for clients. If social workers have psychological distress, low job satisfaction, and conflicting job emotions, their services for the clients will be severely affected. To achieve the goal of better serving others, social workers should have a good state of mind.

Reciprocal Relationship Between Self-Control Belief and Gaming Disorder in Children and Adolescents: Longitudinal Survey Study.

Background: Children and adolescents are often at the crossroads of leisure gaming and excessive gaming. It is essential to identify the modifiable psychosocial factors influencing gaming disorder development. The lay theories of self-control (ie, the beliefs about whether self-control can be improved, also called self-control mindsets) may interplay with self-control and gaming disorder and serve as a promising influential factor for gaming disorder.

The impact of industrial synergistic agglomeration on residents' health levels.

Introduction: This study investigates the impact of industrial synergistic agglomeration on residents' health levels in China. It explores how green and traditional industry agglomeration models influence residents' health levels outcomes and identifies the underlying mechanisms driving these effects.

Methods: Using panel data from 283 prefecture-level cities and above in China from 2003 to 2020, the study applies the Generalized Spatial Two-Stage Least Squares (GS2SLS) method.

VRx@Home protocol: A virtual reality at-home intervention for persons living with dementia and their care partners.

Introduction: Virtual reality (VR) technology is increasingly used by researchers and healthcare professionals as a therapeutic intervention to improve the quality of life of persons living with dementia (PLwD). However, most VR interventions to date have mainly been explored in long-term or community care settings, with fewer being explored at home. Setting is important, given that the majority of PLwD live at home and are cared for by their family care partners.

Chronic Jet Lag Disrupts Circadian Rhythms and Induces Hyperproliferation in Murine Lacrimal Glands via ROS Accumulation.

Purpose: Chronic jet lag (CJL) is known to disrupt circadian rhythms, which regulate various physiological processes, including ocular surface homeostasis. However, the specific effects of CJL on lacrimal gland function and the underlying cellular mechanisms remain poorly understood.

Methods: A CJL model was established using C57BL/6J mice.

Leptin Receptor Deficiency-Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome.

Purpose: This study investigated the impact of hyperglycemia in type 2 diabetes mellitus (T2DM) on the circadian rhythms and function of lacrimal glands (LGs) in contributing to dry eye syndrome. We assessed the effects of hyperglycemia on circadian gene expression, immune cell recruitment, neural activity, and metabolic pathways, and evaluated the effectiveness of insulin in restoring normal LG function.

Methods: Using a T2DM mouse model (db/db mice), circadian transcriptomic changes in LGs were analyzed through RNA sequencing over a 24-hour period.

Enhanced wind mixing and deepened mixed layer in the Pacific Arctic shelf seas with low summer sea ice.

The Arctic Ocean has experienced significant sea ice loss over recent decades, shifting towards a thinner and more mobile seasonal ice regime. However, the impacts of these transformations on the upper ocean dynamics of the biologically productive Pacific Arctic continental shelves remain underexplored. Here, we quantified the summer upper mixed layer depth and analyzed its interannual to decadal evolution with sea ice and atmospheric forcing, using hydrographic observations and model reanalysis from 1996 to 2021.

Tyrosylprotein Sulfotransferase Positively Regulates Symbiotic Nodulation and Root Growth.

Posttranslational tyrosine sulfation of peptides and proteins is catalysed by tyrosylprotein sulfotransferases (TPSTs). In Arabidopsis, tyrosine sulfation is essential for the activities of peptide hormones, such as phytosulfokine (PSK) and root meristem growth factor (RGF). Here, we identified a TPST-encoding gene, MtTPST, from model legume Medicago truncatula.

Long-term high fructose intake reprograms the circadian transcriptome and disrupts homeostasis in mouse extra-orbital lacrimal glands.

This study aims to explore the effects of long-term high fructose intake (LHFI) on the structure, functionality, and physiological homeostasis of mouse extra-orbital lacrimal glands (ELGs), a critical component of ocular health. Our findings reveal significant reprogramming of the circadian transcriptome in ELGs following LHFI, alongside the activation of specific inflammatory pathways, as well as metabolic and neural pathways. Notably, LHFI resulted in increased inflammatory infiltration, enhanced lipid deposition, and reduced nerve fiber density in ELGs compared to controls.

Analysis of the heterogeneity and complexity of murine extraorbital lacrimal gland via single-cell RNA sequencing.

Purpose: The lacrimal gland is essential for maintaining ocular surface health and avoiding external damage by secreting an aqueous layer of the tear film. However, a healthy lacrimal gland's inventory of cell types and heterogeneity remains understudied.

Methods: Here, 10X Genome-based single-cell RNA sequencing was used to generate an unbiased classification of cellular diversity in the extraorbital lacrimal gland (ELG) of C57BL/6J mice.

Unambiguous Models and Machine Learning Strategies for Anomalous Extreme Events in Turbulent Dynamical System.

Data-driven modeling methods are studied for turbulent dynamical systems with extreme events under an unambiguous model framework. New neural network architectures are proposed to effectively learn the key dynamical mechanisms including the multiscale coupling and strong instability, and gain robust skill for long-time prediction resistive to the accumulated model errors from the data-driven approximation. The machine learning model overcomes the inherent limitations in traditional long short-time memory networks by exploiting a conditional Gaussian structure informed of the essential physical dynamics.

S1PR3 inhibition protects against LPS-induced ARDS by inhibiting NF-κB and improving mitochondrial oxidative phosphorylation.

Background: Inflammation and endothelial barrier dysfunction are the major pathophysiological changes in acute respiratory distress syndrome (ARDS). Sphingosine-1-phosphate receptor 3 (S1PR3), a G protein-coupled receptor, has been found to mediate inflammation and endothelial cell (EC) integrity. However, the function of S1PR3 in ARDS has not been fully elucidated.

A Thermosalient and Mechanically Compliant Organic Crystalline Optical Waveguide Switcher.

The dense and ordered molecular arrangements endow dynamic molecular crystals with fast response, rapid energy conversion, low energy dissipation, and strong coupling between heat/light and mechanical energy. Most of the known dynamic crystals can only respond to a single stimulus, and materials that can respond to multiple stimuli are rare. Here, we report an organic crystalline material that can be bent plastically and is also thermosalient, as its crystals can move when they undergo a reversible phase transition.

Chronic sleep deprivation impairs retinal circadian transcriptome and visual function.

Sleep loss is common in modern society and is increasingly associated with eye diseases. However, the precise effects of sleep loss on retinal structure and function, particularly on the retinal circadian system, remain largely unexplored. This study investigates these effects using a chronic sleep deprivation (CSD) model in mice.

Activated Clec4n Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7-Dependent Manner.

The role of endothelial cells in acute lung injury (ALI) has been widely elaborated, but little is known about the role of different subtypes of endothelial cells in ALI. ALI models were established by lipopolysaccharide. Single-cell RNA sequencing was used to identify differential molecules in endothelial subtypes and the heterogeneity of lung immune cells.

Adverse childhood experiences, emotional distress and dissatisfaction with motherhood among first-time mothers: Mediations and child differences.

Despite the challenges associated with motherhood, studies have not consistently identified factors contributing to first-time mothers' dissatisfaction with motherhood in resource-limited regions. To fill this research gap, this study investigates how adverse childhood experiences (ACEs) result in first-time mothers' dissatisfaction with motherhood through emotional distress in Nigeria. Results from the partial least square structural equation model suggests that ACEs are associated with dissatisfaction with motherhood ( = 0.

Split & Join: An Efficient Approach for Simulating Stapled Intestinal Anastomosis in Virtual Reality.

Colorectal cancer is a life-threatening disease. It is the second leading cause of cancer-related deaths in the United States. Stapled anastomosis is a rapid treatment for colorectal cancer and other intestinal diseases and has become an integral part of routine surgical practice.

Dynamics of the surface carbonate system in oil fields with a high concentration of wells on the northwestern South China Sea shelf.

Oil exploitation may pose adverse effects on marine ecosystems, but its impacts on surface carbonate dynamics remain unknown. In a carbonate system with low air-sea ∆pCO, such as the South China Sea (SCS), human activities may affect the pCO distribution patterns and potentially alter CO sink or source at the surface. This study investigates the surface carbonate system in two oil fields, namely the Wenchang Oil Feld and Enping Oil Feld, located on the northwestern SCS (NWSCS) shelf.

Phytosulfokine peptides, their receptors, and functions.

Phytosulfokines (PSKs) are a class of disulfated pentapeptides and are regarded as plant peptide hormones. PSK-α, -γ, -δ, and -ϵ are four bioactive PSKs that are reported to have roles in plant growth, development, and immunity. In this review, we summarize recent advances in PSK biosynthesis, signaling, and function.

Woven organic crystals.

Woven architectures are prepared by physical entanglement of fibrous components to expand one-dimensional material into two-dimensional sheets with enhanced strength and resilience to wear. Here, we capitalize on the elastic properties of long organic crystals with a high aspect ratio to prepare an array of centimeter-size woven network structures. While being robust to mechanical impact, the woven patches are also elastic due to effective stress dissipation by the elasticity of the individual warp and weft crystals.

Single-session intervention on growth mindset on negative emotions for university student mental health (U-SIGMA): a protocol of two-armed randomized controlled trial.

Background: The university years are a developmentally crucial phase and a peak period for the onset of mental disorders. The beliefs about the changeability of negative emotion may play an important role in help-seeking. The brief digital growth mindset intervention is potentially scalable and acceptable to enhance adaptive coping and help-seeking for mental health needs in university students.