Publications by authors named "Di Ja Lasham"
Article Synopsis
- The study examines the genetic characteristics of influenza A(H1N1)pdm09 strains found in Myanmar between 2015 and 2019, utilizing advanced sequencing techniques to analyze 60 virus isolates.
- It identifies distinct clades for each year’s virus, noting that strains from these years were genetically different from WHO-recommended Southern Hemisphere vaccine strains.
- The researchers also discovered a virus with reassortment and three strains with the H275Y mutation, indicating reduced effectiveness against antiviral treatments, highlighting the need for ongoing monitoring of flu virus genetics for vaccine development.
Article Synopsis
- Enterovirus D68 (EV-D68) is a reemerging virus linked to serious respiratory infections and paralysis, mainly affecting children, with outbreaks reported in various regions since 2014 but not in Southeast Asia until now.
- A study in Myanmar collected nasopharyngeal swabs from children aged 1 month to 12 years admitted with acute lower respiratory infections, using a specialized PCR method to detect EV-D68.
- The study found EV-D68 in 42 out of 570 samples (7.4%), with all strains identified as clade B3, marking the first detection of this virus in children in Yangon and highlighting the need for ongoing surveillance in Southeast Asia.
Protein kinases are responsible for protein phosphorylation and are involved in important intracellular signal transduction pathways in various cells, including neurons; however, a considerable number of poorly characterized kinases may be involved in neuronal development. Here, we considered mitogen-activated protein kinase kinase kinase kinases (MAP4Ks), related to as candidate regulators of neurite outgrowth and synaptogenesis, by examining the effects of a selective MAP4K inhibitor PF06260933. PF06260933 treatments of the cultured neurons reduced neurite lengths, not the number of synapses, and phosphorylation of GAP43 and JNK, relative to the control.
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- Parechovirus-A (PeV-A) is an emerging virus affecting children, with symptoms varying by genotype, but research has mostly focused on developed countries, leaving a knowledge gap in places like Myanmar.* -
- This study analyzed nasopharyngeal samples from hospitalized children aged 1 month to 12 years at Yankin Children Hospital over two years to detect and genotype PeV-A.* -
- Out of 570 samples, 11 were positive for PeV-A, revealing four different genotypes in Myanmar, with a median patient age of 10 months, indicating the need for further research on its clinical effects.*
Background: Acute lower respiratory infection (ALRI) remains the leading cause of death in children worldwide, and viruses have been the major cause of ALRI. In Myanmar, ALRI is associated with high morbidity and mortality in children, and detailed information on ALRI is currently lacking.
Methods: This prospective study investigated the viral aetiologies, clinical manifestations, and outcomes of ALRI in hospitalised children aged 1 month to 12 years at the Yankin Children Hospital, Yangon, Myanmar from May 2017 to April 2019.
We aimed to analyze the situation of the first two epidemic waves in Myanmar using the publicly available daily situation of COVID-19 and whole-genome sequencing data of SARS-CoV-2. From March 23 to December 31, 2020, there were 33,917 confirmed cases and 741 deaths in Myanmar (case fatality rate of 2.18%).
View Article and Find Full Text PDFA community outbreak of human influenza A(H1N1)pdm09 virus strains was observed in Myanmar in 2017. We investigated the circulation patterns, antigenicity, and drug resistance of 2017 influenza A(H1N1)pdm09 viruses from Myanmar and characterized the full genome of influenza virus strains in Myanmar from in-patients and out-patients to assess the pathogenicity of the viruses. Nasopharyngeal swabs were collected from out-patients and in-patients with acute respiratory tract infections in Yangon and Pyinmana City in Myanmar during January-December 2017.
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