Publications by authors named "Dhup Bhukdee"
Objectives: This study assessed the real-world relative vaccine effectiveness of the ChAdOx1/AZD1222 vaccine given intradermally at one-fifth dose compared to the standard intramuscular injection, following the completion of 2 doses of CoronaVac, due to limited vaccine availability in Thailand during the Coronavirus disease 2019 (COVID-19) pandemic.
Method: This retrospective cohort study used 138,264 records from Vachira Phuket Hospital, Phuket, Thailand. The records were divided into 2 groups: 49,387 recipients received one-fifth doses via intradermal injections, and 88,877 recipients received standard-dose intramuscular injections from September 14 to October 3, 2021, with follow-up until December 31, 2021.
Article Synopsis
- - The CMS classification for colorectal cancer, established in 2015, identifies four subtypes based on unique molecular signatures that help predict prognosis and treatment response, but significant gaps in understanding cancer progression remain due to non-tumor cell interference in current data.
- - A new gene panel of 62 genes has been proposed that not only captures the original CMS characteristics but also reveals three additional subpopulations, enhancing the understanding of intra-subtype heterogeneity and their correlation with immune cell markers in the tumor microenvironment.
- - The study also includes a 2D visualization of the CMS structure, providing detailed insights into functional pathways and cell types involved in cancer progression, which could facilitate the discovery of new molecular mechanisms in colorectal cancer.