Exploring patient and health care provider perspectives on barriers to diabetic retinopathy screening in public health facilities in North India.

Diabetic retinopathy (DR), a prevalent microvascular complication of diabetes mellitus (DM), can be prevented with early detection and timely intervention. DR is asymptomatic in its early stages, highlighting the importance of screening for accurate referral and effective management. Multiple barriers impede access to diabetic retinopathy screening (DRS), creating significant public health challenges in regions with high DM prevalence.

Evaluation of Pyrrolone-Fused Benzosuberene MK2 Inhibitors as Promising Therapeutic Agents for HNSCC: In Vitro Efficacy, In-Vivo Safety, and Pharmacokinetic Profiling.

MAPKAPK2/MK2 is well implicated in the progression of Head and Neck Squamous Cell Carcinoma (HNSCC), and potent MK2-inhibitors are required to suppress its activity. Several MK2-inhibitors have been developed in recent years to combat its effects on cancer. However, inadequate solubility, insufficient cellular permeability, systemic toxicity-mediated side effects, and low bioavailability have severely impeded the advancement of MK2-inhibitors to clinical trials.

An AQbD driven stability indicating HPLC method for simultaneous estimation of lamivudine, tenofovir disoproxil fumarate and efavirenz in plasma.

The increasing prevalence of HIV has made us rely on a fixed dose combination (FDC) of anti-retroviral agents including lamivudine (LVD), tenofovir disoproxil fumarate (TDF) and efavirenz (EFZ) to ensure better therapeutic outcomes. In this context, the present study aims to develop and optimize Analytical Quality by Design (AQbD) employing D-optimal and Box-Behnken designs to simultaneously estimate LVD, TDF, and EFZ in a FDC. The optimized mobile phase (pH 4.

A perspective on small molecules targeting the renin-angiotensin-aldosterone system and their utility in cardiovascular diseases: exploring the structural insights for rational drug discovery and development.

Renin-angiotensin-aldosterone system (RAAS) is crucial in cardiovascular homeostasis. Any disruption in this homeostasis often leads to numerous cardiovascular diseases (CVDs) and non-cardiovascular diseases. Small molecules that show ability toward mechanically modulating RAAS components have been developed to address this problem, thus providing opportunities for innovative drug discovery and development.

Persistent labial adhesions in a reproductive-age patient masquerading as urethrovaginal fistula.

Labial adhesion in a reproductive-age woman is a rare entity. A woman in her 30s presented with complaints of passage of urine and menstrual blood from the same opening since menarche. The patient underwent some corrective surgery for the same, but the symptoms did not resolve.

Psychometric properties of Child Sensory Profile-2 (CSP-2) among children with spastic cerebral palsy.

Unlabelled: Cerebral palsy (CP) is not just caused by neuromuscular abnormalities; it is also a result of an impaired sensory system. Since there is not a standardized measure to evaluate sensory processing of children with spastic CP, therefore an in-depth assessment of sensory processing deficits in children with spastic CP would require an understanding of the validity and reliability of the Child Sensory Profile-2 (CSP-2) in children with spastic CP. The sample of this study included 230 children with spastic CP aged 3 to 14 years who referred to different paediatric rehabilitation centres of Delhi-NCR from April 2021 and September 2023 by using the snowball sampling procedure.

Massive haemoperitoneum from an unidentified source in a woman with vWD.

Von Willebrand's disease (vWD) is an inherited coagulopathy. In women, this condition can present as periovulatory intra-abdominal bleeding or bleeding from the corpus luteum. A diagnosed case of vWD presented as an emergency with nausea, acute abdominal pain and dizziness.

Enzymatic Reaction Network-Driven Polymerization-Induced Transient Coacervation.

A living cell has a highly complex microenvironment whereas numerous enzyme-driven processes are active at once. These procedures are incredibly accurate and efficient, although comparable control has not yet been established in vitro. Here, we design an enzymatic reaction network (ERN) that combines antagonistic and orthogonal enzymatic networks to produce adjustable dynamics of ATP-fueled transient coacervation.

Strain induced crystal lattice softening and improved thermoelectric performance of hydrogenated silicene for energy harvesting applications.

In recent years, Silicene has attracted great interest in various fields but does not fit well in the field of thermoelectrics due to the absence of electronic band gap. Nevertheless, hydrogenation of silicene (SiH) delocalize the free electrons and induces gap widening (2.19 eV), but its thermoelectric performance is still limited due to the larger band gap.

Discovery of novel pyrrolo[2,3-d]pyrimidine derivatives as anticancer agents: virtual screening and molecular dynamic studies.

CDK/Cyclins are dysregulated in several human cancers. Recent studies showed inhibition of CDK4/6 was responsible for controlling cell cycle progression and cancer cell growth. In the present study, atom-based and field-based 3D-QSAR, virtual screening, molecular docking and molecular dynamics studies were done for the development of novel pyrrolo[2,3-d]pyrimidine (P2P) derivatives as anticancer agents.

Medicinal chemistry-based perspectives on thiophene and its derivatives: exploring structural insights to discover plausible druggable leads.

Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in the US FDA drug approval of small drug molecules, with around 7 drug approvals over the last decade. The present review covers USFDA-approved drugs possessing a thiophene ring system.

Targeting Menin in Acute Myeloid Leukemia: Therapeutic Advances and Future Directions.

Germline mutations in the gene encoding menin protein cause multiple endocrine neoplasia type 1 (MEN1) syndrome. Recent evidence suggests that inhibiting the interaction of menin with its crucial oncogenic protein partners represents a promising therapeutic strategy to AML. Menin plays a critical role in lysine methyltransferase 2A ()-gene-rearranged and -m acute leukemias, both associated with adverse outcomes with current standard therapies, especially in the relapsed/refractory setting.

Development of flame retardant slow release insecticides paint and testing its efficacy for four years against dengue and malaria vectors.

Insecticide based paint formulations have been available since years, however the concept of using such paint products at household level did not get attention due to various reasons. The advancement in insecticidal paint technology has steered toward the development and evaluation of such formulations for use against arthropod vectors. The improved insecticidal paint formulations may contain two or more active agents, hence could display different type of activity against the target vectors.

Mechanistic insights and therapeutic potential of astilbin and apigenin in diabetic cardiomyopathy.

Diabetic cardiomyopathy (DCM) represents a critical complication of Diabetes mellitus (DM), characterized by structural and functional changes in the myocardium independent of coronary artery disease or hypertension. Emerging evidence highlights the significant roles of phytochemicals, particularly astilbin and apigenin, in modulating key molecular pathways implicated in DCM. This review synthesizes current mechanistic insights and therapeutic potential of these compounds, focusing on their interactions with AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptors (PPARs), O-linked N-acetylglucosamine (O-GlcNAc), sodium-glucose co-transporter 2 (SGLT2), protein kinase C (PKC), nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK) pathways.

Diabetic Cardiomyopathy: An Update on Emerging Pathological Mechanisms.

Diabetic Cardiomyopathy (DCM) is a notable consequence of diabetes mellitus, distinguished by cardiac dysfunction that occurs separately from coronary artery disease or hypertension. A recent study has revealed an intricate interaction of pathogenic processes that contribute to DCM. Important aspects involve the dysregulation of glucose metabolism, resulting in heightened oxidative stress and impaired mitochondrial function.

Harnessing Competitive Interactions to Regulate Supramolecular "Micelle-Droplet-Fiber" Transition and Reversibility in Water.

The supramolecular assembly of proteins into irreversible fibrils is often associated with diseases in which aberrant phase transitions occur. Due to the complexity of biological systems and their surrounding environments, the mechanism underlying phase separation-mediated supramolecular assembly is poorly understood, making the reversal of so-called irreversible fibrillization a significant challenge. Therefore, it is crucial to develop simple model systems that provide insights into the mechanistic process of monomers to phase-separated droplets and ordered supramolecular assemblies.

Aquaporin proteins: A promising frontier for therapeutic intervention in cerebral ischemic injury.

Cerebral ischemic injury is characterized by reduced blood flow to the brain, remains a significant cause of morbidity and mortality worldwide. Despite improvements in therapeutic approaches, there is an urgent need to identify new targets to lessen the effects of ischemic stroke. Aquaporins, a family of water channel proteins, have recently come to light as promising candidates for therapeutic intervention in cerebral ischemic injury.

Impact of planting density and shoot thinning on alstroemeria flowering, soil attributes and cost economics.

A field experiment was conducted to assess the impact of various planting densities and levels of shoot thinning on cut flower yield, quality, soil chemical properties and cost economics in the commercially cultivated alstroemeria cultivar 'Capri'. The experiment involved three planting densities (4, 6 and 8 plants/m) along with three shoot thinning levels (10 %, 20 % and 30 %). It was observed that higher planting density (4 plants/m) promoted the length of cut stem, early bud formation, and flowering, optimal quality parameters, including maximum stem thickness, cut stem weight, floret quantity/stem, floret size, number of flowering stems/plant (yield) and vase life.

Factors Predicting Nonadherence to Treatment Recommendations for Patients With Chronic Low Back Pain in India: A Cross-Sectional Survey.

Objective: The purpose of this study was to examine patients' expectations and factors that influence adherence to physiotherapists' treatment recommendations on chronic low back pain (CLBP).

Method: One hundred and forty seven patients with CLBP were included in this study. Predictive indicators including demographic information, views, expectations, and opinions regarding the health status and treatment expectations of patients were derived from questionnaires.

Gallium recovery from red mud: Integration of solvent extraction and siderophore assisted technologies.

Gallium (Ga) recovery from the red mud, though important has never been successful due to several technical and economic reasons such as contaminant interference and the high cost of membranes due to their faster saturation resulting in the clogging of membranes with contaminants. This study demonstrated the recovery of Ga by a combination of HCl-based leaching, Fe/Al/Ti separation, and recovery of Ga using Cyphos IL 104-based solvent extraction and complexation of Ga with desferrioxamine B as a proof-of-principle of the GaLIophore technology. The main leaching parameters such as concentrations of acids, time and temperature of the reaction, and solid-to-liquid ratio have been systematically investigated.

Novel Approach of Nanophotonic Electron Transfer for Augmenting Photosynthesis in : A Biophysical Rationale behind the Plasmonic Enhancement of Chemical Energy Transfer.

Plant photosynthetic machinery is the main source of acquisition and conversion of solar energy to chemical energy with the capacity for autonomous self-repair. However, the major limitation of the chloroplast photosystem is that it can absorb light only within the visible range of the spectrum, which is roughly 50% of the incident solar radiation. Moreover, the photosynthetic apparatus is saturated by less than 10% of available sunlight.

Advancements in targeting tumor suppressor genes (p53 and BRCA 1/2) in breast cancer therapy.

Globally, among numerous cancer subtypes, breast cancer (BC) is one of the most prevalent forms of cancer affecting the female population. A female's family history significantly increases her risk of developing breast cancer. BC is caused by aberrant breast cells that proliferate and develop into tumors.