Exact envelope solitons in topological Floquet insulators.

The existence of new types of four-wave mixing Floquet solitons were recently realized numerically through a resonant phase matching in a photonic lattice of type-I Dirac cones; specifically, a honeycomb lattice of helical array waveguides imprinted on a weakly birefringent medium. We present a wide class of exact solutions in this system for the envelope solitons in dark-bright pairs and a "molecular" form of bright-dark combinations. Some of the solutions, red or blue detuned, are mode-locked in their momenta, while the others offer a spectrum of allowed momenta subject to constraints amongst the system and solution parameters.

Dissecting the contributions of membrane affinity and bivalency of the spider venom protein DkTx to its sustained mode of TRPV1 activation.

The spider venom protein, double-knot toxin (DkTx), partitions into the cellular membrane and binds bivalently to the pain-sensing ion channel, TRPV1, triggering long-lasting channel activation. In contrast, its monovalent single knots membrane partition poorly and invoke rapidly reversible TRPV1 activation. To discern the contributions of the bivalency and membrane affinity of DkTx to its sustained mode of action, here, we developed diverse toxin variants including those containing truncated linkers between individual knots, precluding bivalent binding.

The efficient operating parameter estimation for a simulated plug-in hybrid electric vehicle.

Hybrid electric vehicles (HEVs) and plug-in HEVs (PHEVs) are indispensable tools in reducing greenhouse gas emissions to fight the twin evils of pollution and climate change. In these vehicles, battery replacement and fuel costs are the major recurring costs over a lifetime. Hence, there is a growing attempt to develop strategies that reduce the long-run expenditure in these vehicles without compromising on performance levels.

Oral Brush Liquid-Based Cytology: A Study of Concordance between a Cytotechnologist and a Cytopathologist.

Objective: Oral cancer accounts for almost 40% of all cancers in the Indian subcontinent. Techniques like oral scrape cytology are helpful in early diagnosis of premalignant lesion and thus prevention of malignant transformation. The purpose of this study is to evaluate the performance of cytotechnologists in assessing the adequacy and preliminary diagnostic accuracy of oral brush liquid-based cytology.