Gastrointestinal stromal tumour of stomach: Feasibility of laparoscopic resection in large lesions and its long-term outcomes.

Background: Gastric gastrointestinal stromal tumours (GISTs) are rare neoplasms that require excision for cure. Although the feasibility of laparoscopic resection of smaller gastric GIST has been established, the feasibility and long-term efficacy of these techniques are unclear in larger lesions. This study is done to assess the feasibility of the laparoscopic resection of gastric GISTs and their long-term outcomes.

Laparoscopic choledochoduodenostomy as a reliable rescue procedure for complicated bile duct stones.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) with stone extraction is generally accepted as first line management for common bile duct (CBD) stones. CBD exploration, either by open or laparoscopic approach nowadays, is usually reserved for ERCP failures, complicated stone locations, along with altered anatomical situations. The aim of this study was to highlight the increasing role of laparoscopic choledochoduodenostomy which is not only a reliable but also as a rescue procedure for those failed ERCP cases due to complicated bile duct stones.

Duplication cyst of pyloric canal: a rare cause of pediatric gastric outlet obstruction: rare case report.

Duplication of the alimentary tract may occur in any site, from the mouth to the anus, and in recent years such anomalies have received wide notice. Pyloric duplication cyst is an extremely rare congenital anomaly of the alimentary tract, whose clinical presentation often mimics those of hypertrophic pyloric stenosis. Gastrointestinal duplications are observed in 1 of every 4500 autopsies, predominantly in white males.

Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance.

Caspase-3 is a member of the cysteine protease family, which plays a crucial role in apoptotic pathways by cleaving a variety of key cellular proteins. Caspase-3 can be activated by diverse death-inducing signals, including the chemotherapeutic agents. The purpose of this study was to determine the levels of caspase-3 expression in breast tumor samples and to determine whether alterations in its expression can affect their ability to undergo apoptosis.