Publications by authors named "Dhaval K Shukal"
Growth factor-induced migration of lens epithelial cell (LEC) toward the posterior of lens capsule bag and their epithelial-mesenchymal transition (EMT) is the key process involved in the pathogenesis of posterior capsular opacification (PCO). Silibinin, a natural flavonolignan, confers therapeutic effects to different cells by regulation of signalling pathways; however, its role in the prevention of migration and EMT of LECs is yet to be analysed. In this study, the inhibitory capabilities of silibinin on migration and EMT were analysed in response to TGFβ2 stimulation in HLE B-3 cells.
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- - AMP-activated protein kinase (AMPK) is an essential regulator of energy balance in cells, activated during low energy conditions, making it a key target for treating diseases, particularly those affecting the eyes.
- - The review examines how AMPK signaling is involved in the development of various ocular diseases like cataracts, glaucoma, and diabetic retinopathy, linking it to processes like mitochondrial biogenesis and inflammation.
- - The study suggests that inhibiting AMPK signaling may be more effective for treating ocular diseases than activating it, highlighting the need for research into better AMPK modulators for eye-related treatments.