Publications by authors named "Dharshini Singaravelu"
Article Synopsis
- The rise of antimicrobial-resistant strains is a major threat to existing treatments, highlighting the need for new therapies.
- Researchers developed a new compound, QPyNATh, by modifying thiazolidine with fatty acids to enhance its ability to disrupt bacterial membranes, showing effective inhibition against Gram-positive bacteria while being selective for bacterial cells over human cells.
- Animal studies demonstrated that QPyN16Th significantly reduced MRSA infections in zebrafish and showed no signs of resistance developing, suggesting its potential as a biocompatible treatment for resistant bacterial infections.
Targeted drug delivery maximizes the chance to combat infection caused by drug-resistant pathogens. Herein, lectin-fortified cationic copper sulfide (cCuS) nanoparticles were suggested for targeted adhesion to bacterial membranes and to enforce bacterial death. Jacalin, a lectin from jackfruit seed, was conjugated to fluorescein isothiocyanate (FITC), and its ability to recognize bacterial cell surface glycans was demonstrated.
View Article and Find Full Text PDFIn this paper, the application of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) synthesized using a biomimetic lipid, N-myristoyltaurine (N14T) was evaluated in common fields. The catalytic effectiveness of AgNPs and AuNPs was studied in the popular nanocatalyst reaction, nitroaromatic reduction, and dye degradation. Both NPs display catalytic activity in the nitroaromatic compound and organic dyes reduction reaction involving sodium borohydride and the rate constant is estimated as 10 s.
View Article and Find Full Text PDFAim: Polymicrobial biofilm encasing cross-kingdom micro-organisms are apparent in medicine, which imposes serious resistance to conventional antimicrobial treatment. The objective of the study was to explore Butea monosperma seed lectin (BMSL) conjugated antimicrobial lipid, 2-((N-[2-hydroxyethyl]palmitamido)methyl)-1-methylpyridin-1-ium iodide (cN16E) to inhibit mixed-species biofilm of uropathogenic Escherichia coli-Candida albicans.
Methods And Results: Antimicrobial activity and antibiofilm of cN16E and cN16E-BMSL conjugate (BcN16E) were analysed against single- and mixed microbial cultures.