Publications by authors named "Dharshana Sabanayagam"

Article Synopsis
  • The KDIGO Clinical Practice Guideline for Chronic Kidney Disease (CKD) updates the 2012 guideline, reflecting a comprehensive review of new evidence and advancements in treatment but does not apply to dialysis patients or those with transplants.
  • The guideline addresses evaluation, risk assessment, and management strategies to slow CKD progression, using a systematic approach to assess the quality and strength of recommendations.
  • It includes practice points, infographics, and highlights future research needs, aiming to serve a wide audience and consider implications for healthcare policies and payment systems.*
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People living with chronic kidney disease (CKD) often experience multimorbidity and require polypharmacy. Kidney dysfunction can also alter the pharmacokinetics and pharmacodynamics of medications, which can modify their risks and benefits; the extent of these changes is not well understood for all situations or medications. The principle of drug stewardship is aimed at maximizing medication safety and effectiveness in a population of patients through a variety of processes including medication reconciliation, medication selection, dose adjustment, monitoring for effectiveness and safety, and discontinuation (deprescribing) when no longer necessary.

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