Publications by authors named "Dharmesh Paliwal"

 Gallbladder cancer (GBC) is one of the most common and aggressive malignancies of the Indo-Gangetic plains. Despite its widespread use in GBC cases, the role of 18-flurodeoxyglucose positron emission tomography-computed tomography ( FDG PET-CT) in the management of this disease is not well defined. In our study, we present the practice trends of the utilization of this investigative modality in our hospital and its benefits in aiding diagnosis, staging, and surveillance for recurrence.

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 Flourine-18 fluorodeoxyglucose positron emission tomography-computed tomography ( F-FDG PET-CT) is a well-established imaging modality for the evaluation of patients with oncological and nononcological conditions. The underlying principle of imaging is the preferentially increased glucose consumption by cancer cells, due to overexpression of glucose type 1 receptors that are insulin independent. Thus, one of the factors that leads to decreased sensitivity of an F-FDG PET-CT is elevated blood sugar levels, leading to decreased glucose uptake by cancer cells due to competitive inhibition.

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Article Synopsis
  • A 35-year-old pregnant woman, 15 weeks along, was diagnosed with advanced breast cancer and was recommended to terminate her pregnancy before undergoing imaging for cancer staging.
  • Due to concerns about potential COVID-19 exposure, the patient opted to have the necessary PET-CT scan before the medical termination of pregnancy, which revealed extensive cancer spread and physiological FDG uptake in the fetus.
  • The case highlights important considerations regarding fetal radiation safety and measures to minimize exposure during cancer treatment and imaging procedures.
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Adenocarcinoma cervix is an uncommon histological subtype of carcinoma cervix; further incidence of skeletal muscle metastases is even rarer. We report the identification of extensive fluorodeoxyglucose (FDG) avid metastatic skeletal muscle deposits in a known case of adenocarcinoma cervix. The largest lesion representative of muscle deposit in the right deltoid was histopathologically confirmed to be metastatic poorly differentiated carcinoma.

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