Monodentate Phosphinoamine Nickel Complex Supported on a Metal-Organic Framework for High-Performance Ethylene Dimerization.

Ethylene dimerization is an efficient industrial chemical process to produce 1-butene, with demanding selectivity and activity requirements on new catalytic systems. Herein, a series of monodentate phosphinoamine-nickel complexes immobilized on UiO-66 are described for ethylene dimerization. These catalysts display extensive molecular tunability of the ligand similar to organometallic catalysis, while maintaining the high stability attributed to the metal-organic framework (MOF) scaffold.

Possible Fine-Tuning of Methane Activation toward C2 Oxygenates by 3d-Transition Metal-Ions Doped Nano-Ceria-Zirconia.

In this work, we demonstrate a simple sol-gel technique to prepare metal-ion(s)-doped ceria-zirconia solid solution for efficient catalytic methane activation. The cation-depicting formula units are CeZr (CZ), CeZrM (CZM), and CeZrMM (CZMM) (M and M = V, Mn, Fe, Co, and Cu), employed for undoped, mono-metal-ion-doped, and bi-metal-ion-doped solid solutions, respectively. Methane activation with Mn, Fe, Cu mono-metal-ion-doped CZ favors the C1 product, while CZCo assists C-C coupling with the formation of acetaldehyde.

Progress in COVID research and developments during pandemic.

The pandemic respiratory disease COVID-19 has spread over the globe within a small span of time. Generally, there are two important points are being highlighted and considered towards the successful diagnosis and treatment process. The first point includes the reduction of the rate of infections and the next one is the decrease of the death rate.

Solution Combustion Synthesis of Novel S,B-Codoped CoFe Oxyhydroxides for the Oxygen Evolution Reaction in Saline Water.

Green hydrogen presents itself as a clean energy vector, which can be produced by electrolysis of water by utilizing renewable energy such as solar or wind. While current technologies are sufficient to support commercial deployment of fresh water electrolyzers, there remain a few well-defined challenges in the path of commercializing direct seawater electrolyzers, predominantly related to the sluggish oxygen evolution reaction (OER) kinetics and the competing chlorine evolution reaction (CER) at the anode. Herein, we report the facile and swift fabrication of an S,B-codoped CoFe oxyhydroxide via solution combustion synthesis for the OER with apparent CER suppression abilities.

Early Transition-Metal-Based Binary Oxide/Nitride for Efficient Electrocatalytic Hydrogen Evolution from Saline Water in Different pH Environments.

Using abundant seawater can reduce reliance on freshwater resources for hydrogen production from electrocatalytic water splitting. However, seawater has detrimental effects on the stability and activity of the hydrogen evolution reaction (HER) electrocatalysts under different pH conditions. In this work, we report the synthesis of binary metallic core-sheath nitride@oxynitride electrocatalysts [Ni(ETM)]-[O-N], where ETM is an early transition metal V or Cr.

Catalytic Methane Decomposition to Carbon Nanostructures and CO-Free Hydrogen: A Mini-Review.

Catalytic methane decomposition (CMD) is a highly promising approach for the rational production of relatively CO-free hydrogen and carbon nanostructures, which are both important in multidisciplinary catalytic applications, electronics, fuel cells, etc. Research on CMD has been expanding in recent years with more than 2000 studies in the last five years alone. It is therefore a daunting task to provide a timely update on recent advances in the CMD process, related catalysis, kinetics, and reaction products.

Effect of Surface Mechanical Treatments on the Microstructure-Property-Performance of Engineering Alloys.

Fatigue is a dominant failure mechanism of several engineering components. One technique for increasing the fatigue life is by inducing surface residual stress to inhibit crack initiation. In this review, a microstructural study under various bulk (such as severe plastic deformation) and surface mechanical treatments is detailed.

Clinical Profile of Cutaneous Adverse Effects of Epidermal Growth Factor Receptor Inhibitors: A Prospective Observational Study of 76 Cases.

Background: Epidermal growth factor receptor (EGFR) inhibitors are an extensively utilized class of chemotherapeutic agents which form an integral component of treatment in solid organ malignancies such as non-small-cell lung carcinoma, pancreatic carcinoma, colorectal carcinoma, and head and neck carcinoma. It has two subclasses: epidermal growth factor inhibitors (erlotinib) and monoclonal antibody (cetuximab). A wide array of cutaneous adverse effects has been attributed to this class of drugs, such as papulopustular eruptions, paronychia, xerosis, and changes in hair and nails.

Pseudolycorine -oxide, a new -oxide from .

A new -oxide, Pseudolycorine -oxide () was characterised along with eleven known alkaloids homolycorine (), -methylmaritidine (), 8--demethylhomolycorine (), homolycorine -oxide (), lycorine (, narciclasine (), pseudolycorine (), ungeremine (), 8--demethylmaritidine (), zefbetaine () and lycorine -oxide (), from . Their structures were established on the basis of spectroscopic data analysis. The extract, fractions and isolated compounds were screened for cytotoxicity against two human cancer cell lines, human cervical cancer (SiHa) and human epidermoid carcinoma (KB) cells.

Narciclasine-4---D-xylopyranoside, a new narciclasine glycoside from .

A new narciclasine glycoside, narciclasine-4---D-xylopyranoside () was characterised along with four known alkaloids pancratistatin (), 1--(3-hydroxybutyryl) pancratistatin (), vittatine (), 9--demethylgalanthine () from . Their structures were established on the basis of spectroscopic data analysis. The cytotoxic study of extract, fractions and isolated compounds against two human cancer cell lines (KB and SiHa) indicated the potential activity of extract and -butanol fraction due to presence of active alkaloids pancratistatin, 1--(3-hydroxybutyryl) pancratistatin, lycorine and haemanthamine.

Chemical Composition, Cytotoxic and Antibacterial Activities of Essential Oils of Cultivated Clones of Juniperus communis and Wild Juniperus Species.

Needles of seven cultivated clones (C1 - C7) of Juniperus communis at lower altitude and three wild Juniperus species (J. communis, J. recurva and J.

A study of therapy targeted EGFR/ALK mutations in Indian patients with lung adenocarcinoma: A clinical and epidemiological study.

Background: Established predictive biomarkers for Non-Small Cell Lung Carcinoma (NSCLC) include sensitizing Epidermal Growth Factor Receptor (EGFR) mutations and Anaplastic Lymphoma Kinase (ALK) fusion oncogene. The primary aim of the study is to ascertain the prevalence of EGFR mutation and ALK gene rearrangement in patients of lung adenocarcinoma in Indian population and the second objective is to impress upon the importance of adequate processing of limited tissue samples.

Methods: Histopathologically confirmed cases of lung adenocarcinoma, whose tumour had been tested for both EGFR and ALK gene mutations, were included in this study.

Anthocyanins enriched purple tea exhibits antioxidant, immunostimulatory and anticancer activities.

Purple coloured tea shoot clones have gained interest due to high content of anthocyanins in addition to catechins. Transcript expression of genes encoding anthocyanidin reductase (), dihydroflavonol-4-reductase (), anthocyanidin synthase (), flavonol synthase () and leucoantho cyanidin reductase () enzymes in three new purple shoot tea clones compared with normal tea clone showed higher expression of , , and lower expression of and in purple shoot clones compared to normal clone. Expression pattern supported high content of anthocyanins in purple tea.

Development of nanoformulation of picroliv isolated from Picrorrhiza kurroa.

Picroliv, a mixture of picroside I and kutkoside isolated from rhizome of Picrorrhiza kurroa has been reported for many pharmaceutical properties such as hepatoprotective, anticholestatic, antioxidant and immune-modulating activity. However, picroliv possessed lesser efficacy due to its poor aqueous solubility and lesser bioavailability. To find solution, picroliv was loaded into biodegradable poly lactic acid nanoparticles (PLA NPs) using solvent evaporation method.

Reversed-phase high-performance Liquid Chromatography-ultraviolet Photodiode Array Detector Validated Simultaneous Quantification of six Bioactive Phenolic Acids in Roscoea purpurea Tubers and their In vitro Cytotoxic Potential against Various Cell Lines.

Background: Roscoea purpurea or Roscoea procera Wall. (Zingiberaceae) is traditionally used for nutrition and in the treatment of various ailments.

Objective: Simultaneous reversed-phase high-performance liquid chromatography-ultraviolet (RP-HPLC) photodiode array detector identification of phenolic acids (PA's) was carried out in whole extract of tuber and their cytotoxic potential was estimated along with radical scavenging action.

Chemical Composition and In Vitro Cytotoxicity of Essential Oils from Leaves and Flowers of Callistemon citrinus from Western Himalayas.

Background: Plant-based traditional system of medicine continues to play an important role in healthcare. In order to find new potent source of bioactive molecules, we studied the cytotoxic activity of the essential oils from the flowers and leaves of Callistemon citrinus. This is the first report on anticancer potential of essential oils of C.

UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa.

Ethnopharmacological Relevance: Saussurea lappa (Asteraceae) roots have been reputed for the usage in traditional medicinal systems of India, China and Japan for the treatment of various kinds of disorders such as anti-ulcer, anti-convulsant, anti-cancer, hepatoprotective, anti-arthritic and anti-viral activities.

Materials And Methods: Compounds were isolated using a column chromatographic technique. The root extract, fractions and isolated compounds were tested for cytotoxicity against A549 (human lung carcinoma) and C-6 (rat glioma) cells using the Sulphorhodamine B assay.

In vitro cytotoxic activity guided essential oil composition of flowering twigs of Stevia rebaudiana.

The essential oil extracted by hydrodistillation from the flowering twigs of Stevia rebaudiana Bertoni (Asteraceae) was fractioned by chromatography. Forty-three constituents were characterized with the help of GC, GC-MS and other spectroscopic techniques. The essential oil was found to be a complex mixture of mono- and sesqui-terpenes.

Biosurfactant stabilized anticancer biomolecule-loaded poly (D,L-lactide) nanoparticles.

PLA nanoparticles (NPs) were prepared via green route using turmeric (Curcuma longa) extract (TE) as biostabiliser/biosurfactant. Of the 29 formulations, two formulations of TE synthesized PLA NPs were evaluated for encapsulation and controlled release of well known antioxidant and less bioavailable molecules curcumin and quercetin. Size of curcumin loaded PLA NPs synthesized using 0.

Encapsulation of catechin and epicatechin on BSA NPS improved their stability and antioxidant potential.

Nanoencapsulation of antioxidant molecules on protein nanoparticles (NPs) could be an advanced approach for providing stable, better food nutraceuticals and anticancer drugs. The bioavailability and stability of catechin (CAT) and epicatechin (ECAT) were very poor. In the present study, the CAT and ECAT were loaded on bovine serum albumin (BSA) NPs following desolvation method.