Publications by authors named "Dharmendra Ahluwalia"
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Synopsis of recent research by authors named "Dharmendra Ahluwalia"
- Dharmendra Ahluwalia's research primarily focuses on hypoxia-activated prodrugs, particularly TH-302, and their mechanisms and efficacy in targeting tumor hypoxia to enhance anti-tumor activity in various cancer models.
- Recent studies highlight the potential of TH-302 in combination with other treatments, revealing significant improvements in tumor growth inhibition and antitumor efficacy when paired with mTOR inhibitors or traditional chemotherapy agents like gemcitabine and nab-paclitaxel.
- Ahluwalia's work underscores the importance of selectively targeting hypoxic tumor regions, showing how TH-302 can deliver cytotoxic agents effectively while minimizing systemic toxicity, thus addressing a major challenge in cancer therapeutics.
