Biocompatible alkyne arms containing Schiff base fluorescence indicator for dual detection of Cd and Pb at physiological pH and its application to live cell imaging.

An alkyne arms containing salen-type Schiff base ligand, 6,6'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(3-(prop-2-yn-1-yloxy)phenol) (HL), is reported here as a dual chemosensor for Cd and Pb ions. The ligand HL was characterized by various spectral methods. The ligand HL acts as a dual sensor for Cd and Pb in methanol/HEPES buffer (5 mM, pH 7.

A new multifunctional benzimidazole tagged coumarin as ratiometric fluorophore for the detection of Cd/F ions and imaging in live cells.

A novel multifunctional ratiometric fluorescent probe has been designed and synthesized for the selective recognition of Cd/F ions. The probe (3)-((2)-(1H-benzoimidazole-2-yl)-phenylimino) methyl-4-chloro-methyl-2H-chromen-2-ene (BIMC) displays excellent ratiometric responses towards Cd/F ions over the tested cations/anions. The lowest detection limits observed for Cd and F are 1.

Charge transfer based "turn-on" chemosensor for Zn²⁺ ion recognition using new triaryl pyrazoline derivative.

The fluoroionophore PY serves as a selective and fluorimetric chemosensor for Zn(2+) based on charge transfer (CT). A mechanism for the binding mode was proposed based on fluorescence changes, NMR experiments and theoretical calculations. The 1:1 stoichiometry between Zn(2+) and the sensor was deduced from Job's plot.

Triazole based ratiometric fluorescent probe for Zn2+ and its application in bioimaging.

An efficient fluorescent chemosensor 4-((2-hydroxynaphthalen-1-yl)methyleneamino)-3-phenyl-1H-1,2,4-triazole-5(4H)-thione, based on triazole has been designed by condensing 2-hydroxy-1-napthaldehyde with amine, appended to 1,2,4-triazole unit. The probe displays excellent selectivity and sensitivity in both absorbance and fluorescence detection of Zn2+ over other essential metal ions. The nature of fluorescence behavior of receptor upon addition of Zn2+ has been obtained from Density Functional Theory calculations.