Crafting the architecture of biomass-derived activated carbon electrochemical insights for supercapacitors: a review.

Escalating energy demands have often ignited ground-breaking innovations in the current era of electrochemical energy storage systems. Supercapacitors (SCs) have emerged as frontrunners in this regard owing to their exclusive features such ultra-high cyclic stability, power density, and ability to be derived from sustainable sources. Despite their promising attributes, they typically fail in terms of energy density, which poses a significant hindrance to their widespread commercialization.

Anxiety-like behavior and altered hippocampal activity in a transgenic mouse model of Fabry disease.

Background: Fabry disease (FD) patients are known to be at high risk of developing neuropsychiatric symptoms such as anxiety, depression and cognitive deficits. Despite this, they are underdiagnosed and inadequately treated. It is unknown whether these symptoms arise from pathological glycosphingolipid deposits or from cerebrovascular abnormalities affecting neuronal functions in the central nervous system.

Chemically engineered plasmonic Au-gallium oxide nanocomposites for harsh environment applications: an investigation into thermal and chemical robustness.

Enhanced thermal, chemical, and mechanical properties of different metal nanoparticle morphologies integrated with metal oxides have been reported in multiple instances. The chemical and material robustness of metal nanoparticles incorporated surficially and into the bulk of distinct as well as spontaneously formed morphologies of metal oxides through solution-based and microwave-based approaches are investigated in this study. These composites were tested for their chemical and material robustness by exposing films formed on quartz substrates to high temperatures (800 °C) in an air ambient as well as to extreme conditions of pH, often encountered in harsh environment applications such as sensing and catalysis.

Asymmetric Supercapacitors Based on ZnCoO Nanohexagons and Orange Peel Derived Activated Carbon Electrodes.

Herein, the performance of asymmetric supercapacitors (ASC) fabricated using ZnCoO (ZCO) nano-hexagons and orange peel-derived activated carbon (OPAC) as electrodes was studied. ZCO was prepared by a double hydroxide method and OPAC was prepared from orange peel followed by KOH activation. For ZCO, the calcination temperature was determined using TGA analysis.

Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer's disease.

Musculoskeletal chronic pain is prevalent in individuals with Alzheimer's disease (AD); however, it remains largely untreated in these patients, raising the possibility that pain mechanisms are perturbed. Here, we utilise the TASTPM transgenic mouse model of AD with the K/BxN serum transfer model of inflammatory arthritis. We show that in male and female WT mice, inflammatory allodynia is associated with a distinct spinal cord microglial response characterised by TLR4-driven transcriptional profile and upregulation of P2Y12.

Plasmonic nanotechnology for photothermal applications - an evaluation.

The application of plasmonic nanoparticles is motivated by the phenomenon of surface plasmon resonance. Owing to the tunability of optothermal properties and enhanced stability, these nanostructures show a wide range of applications in optical sensors, steam generation, water desalination, thermal energy storage, and biomedical applications such as photothermal (PT) therapy. The PT effect, that is, the conversion of absorbed light to heat by these particles, has led to thriving research regarding the utilization of plasmonic nanoparticles for a myriad of applications.

Oestrogen enforces the integrity of blood vessels in the bone during pregnancy and menopause.

The mammalian skeletal system shows sex differences in structure, functions, ageing and disease incidences. The role of blood vessels in physiological, regenerative and pathological bone functions indicates the requisite to understanding their sex specificity. Here, we find oestrogen regulates blood vessel physiology during pregnancy and menopause through oestrogen receptor alpha (ERα) and G-protein coupled oestrogen receptor-1 (Gper1) but not ERβ-dependent signalling in mice.

Nanomaterial-Based Biosensors using Field-Effect Transistors: A Review.

Field-effect transistor biosensors (Bio-FET) have attracted great interest in recent years owing to their distinctive properties like high sensitivity, good selectivity, and easy integration into portable and wearable electronic devices. Bio-FET performance mainly relies on the constituent components such as the bio-recognition layer and the transducer, which ensures device stability, sensitivity, and lifetime. Nanomaterial-based Bio-FETs are excellent candidates for biosensing applications.

Plasmonic Au-Metal Oxide Nanocomposites for High-Temperature and Harsh Environment Sensing Applications.

Noble metal nanoparticles like Au have long been admired for their brilliant colour, significantly influenced by plasmon resonance. When embedded in metal oxides, they exhibit unique properties which make them an excellent choice for sensing in high-temperature and harsh environment atmospheres. In this review, the various morphologies of Au nanoparticles (AuNPs) used in combination with metal oxides for sensing gases at temperatures greater than 300 °C are discussed.

Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin.

Cornelia de Lange Syndrome (CdLS) is a human developmental disorder caused by mutations that compromise the function of cohesin, a major regulator of 3D genome organization. Cognitive impairment is a universal and as yet unexplained feature of CdLS. We characterize the transcriptional profile of cortical neurons from CdLS patients and find deregulation of hundreds of genes enriched for neuronal functions related to synaptic transmission, signalling processes, learning and behaviour.

XPO7 is a tumor suppressor regulating p21-dependent senescence.

Senescence is a key barrier to neoplastic transformation. To identify senescence regulators relevant to cancer, we screened a genome-wide shRNA library. Here, we describe exportin 7 (XPO7) as a novel regulator of senescence and validate its function in telomere-induced, replicative, and oncogene-induced senescence (OIS).

LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites.

Background: Ligation-mediated PCR protocols have diverse uses including the identification of integration sites of insertional mutagens, integrating vectors and naturally occurring mobile genetic elements. For approaches that employ NGS sequencing, the relative abundance of integrations within a complex mixture is typically determined through the use of read counts or unique fragment lengths from a ligation of sheared DNA; however, these estimates may be skewed by PCR amplification biases and saturation of sequencing coverage.

Results: Here we describe a modification of our previous splinkerette based ligation-mediated PCR using a novel Illumina-compatible adapter design that prevents amplification of non-target DNA and incorporates unique molecular identifiers.

Cardiac glycosides are broad-spectrum senolytics.

Senescence is a cellular stress response that results in the stable arrest of old, damaged or preneoplastic cells. Oncogene-induced senescence is tumor suppressive but can also exacerbate tumorigenesis through the secretion of pro-inflammatory factors from senescent cells. Drugs that selectively kill senescent cells, termed senolytics, have proved beneficial in animal models of many age-associated diseases.

STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse.

Multi-omics approaches use a diversity of high-throughput technologies to profile the different molecular layers of living cells. Ideally, the integration of this information should result in comprehensive systems models of cellular physiology and regulation. However, most multi-omics projects still include a limited number of molecular assays and there have been very few multi-omic studies that evaluate dynamic processes such as cellular growth, development and adaptation.

Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system.

In multicellular organisms, duplicated genes can diverge through tissue-specific gene expression patterns, as exemplified by highly regulated expression of RUNX transcription factor paralogs with apparent functional redundancy. Here we asked what cell-type-specific biologies might be supported by the selective expression of RUNX paralogs during Langerhans cell and inducible regulatory T cell differentiation. We uncovered functional nonequivalence between RUNX paralogs.

Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation.

The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage-specific genes but also the coordinated adaptation of housekeeping functions from a metabolically active, proliferative state toward quiescence. How metabolic and cell-cycle states are coordinated with the regulation of cell type-specific genes is an important question, because dissociation between differentiation, cell cycle, and metabolic states is a hallmark of cancer. Here, we use a model system to systematically identify key transcriptional regulators of Ikaros-dependent B cell-progenitor differentiation.

Author Correction: Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates.

The original version of this Article contained an error in the hyperlink for the online repository http://mulvdb.org which was incorrectly given as http://mulv.lms.

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation.

Cohesin is important for 3D genome organization. Nevertheless, even the complete removal of cohesin has surprisingly little impact on steady-state gene transcription and enhancer activity. Here we show that cohesin is required for the core transcriptional response of primary macrophages to microbial signals, and for inducible enhancer activity that underpins inflammatory gene expression.

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.

Oncogene-induced senescence is a potent tumor-suppressive response. Paradoxically, senescence also induces an inflammatory secretome that promotes carcinogenesis and age-related pathologies. Consequently, the senescence-associated secretory phenotype (SASP) is a potential therapeutic target.

Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates.

Determining whether recurrent but rare cancer mutations are bona fide driver mutations remains a bottleneck in cancer research. Here we present the most comprehensive analysis of murine leukemia virus-driven lymphomagenesis produced to date, sequencing 700,000 mutations from >500 malignancies collected at time points throughout tumor development. This scale of data allows novel statistical approaches for identifying selected mutations and yields a high-resolution, genome-wide map of the selective forces surrounding cancer gene loci.

Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.

Expression of the transcription factors OCT4, SOX2, KLF4, and cMYC (OSKM) reprograms somatic cells into induced pluripotent stem cells (iPSCs). Reprogramming is a slow and inefficient process, suggesting the presence of safeguarding mechanisms that counteract cell fate conversion. One such mechanism is senescence.