Genetically encoding thioacetyl-lysine as a non-deacetylatable analog of lysine acetylation in .

Reversible lysine acetylation is one of the most widely distributed post-translational modifications; it is involved in a variety of biological processes and can be found in all three domains of life. Acetyltransferases and deacetylases work coordinately to control levels of protein acetylation. In this work, we applied the genetic code expansion strategy to site-specifically incorporate -thioacetyl-l-lysine (TAcK) as an analog of -acetyl-l-lysine (AcK) into green fluorescent protein and malate dehydrogenase in .

Dissolution studies and quantification of meloxicam in tablet dosage form by spectrophotometry.

Two simple and inexpensive UV spectrophotometric methods were developed for the quantification and dissolution studies of meloxicam in tablet dosage forms. Meloxicam was estimated at 365nm and 360nm in Method I and Method II, respectively. The calibration curve was linear over a concentration range from 2.