Publications by authors named "Dhanushi Thathsara Welideniya"
Curr Org Synth
August 2021
Article Synopsis
- The synthesis of levothyroxine sodium, a crucial treatment for hypothyroidism, has relied on outdated methods that are inefficient and lack detailed data on intermediates.
- The authors propose a revamped synthesis using modern reagents, improving yields to 39-51% by modifying the original Chalmers synthesis.
- Their improved methodology includes a more effective N-acetylation step and offers practical guidance for producing levothyroxine sodium in laboratory and industrial settings.
