Publications by authors named "Dhanushi T Welideniya"
Beclomethasone dipropionate (1) is a synthetic corticosteroid with anti-inflammatory, antipruritic, and anti-allergy properties. It is widely used to treat asthma, allergic rhinitis, and dermatoses. However, existing synthetic routes to this active pharmaceutical ingredient (API) contain steps resulting in low and/or inconsistent yields, and use obsolete reagents.
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- The synthesis of levothyroxine sodium, a crucial treatment for hypothyroidism, has relied on outdated methods that are inefficient and lack detailed data on intermediates.
- The authors propose a revamped synthesis using modern reagents, improving yields to 39-51% by modifying the original Chalmers synthesis.
- Their improved methodology includes a more effective N-acetylation step and offers practical guidance for producing levothyroxine sodium in laboratory and industrial settings.
During the last three decades, studies of linamarin extracted from cassava have received increased attention due to the presence of high cyanogenic compounds in these extracts. The methods that are utilized to isolate linamarin are either tedious or use acidic conditions resulting in poor yields. In this study, a novel cryocooled method of extraction has been developed to isolate linamarin from Cassava root peel.
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