Publications by authors named "Dhanashri V Ostwal"
J Am Soc Mass Spectrom
February 2020
Article Synopsis
- Cleavable cross-linking technology needs further MS/MS analysis for clear identification of cross-linked peptides, which can be complicated due to sensitivity and fragmentation.
- A new dual cleavable cross-linking technology (DUCCT) utilizes two mass spectrometry methods (CID and ETD) to improve accuracy by providing different signature ions for the same cross-linked peptide.
- The introduction of an enrichment-based photocleavable DUCCT (PC-DUCCT-biotin) and the development of a software tool, Cleave-XL, helps analyze cross-linked products and automate the identification of protein structures with high confidence.
