Green and Regioselective Approach for the Synthesis of 3-Substituted Indole Based 1,2-Dihydropyridine and Azaxanthone Derivatives as a Potential Lead for SARS-CoV-2 and Delta Plus Mutant Virus: DFT and Docking Studies.

Great attempts have been done for the development of novel antiviral compounds against SAR-CoV-2 to end this pandemic situation and save human society. Herewith, we have synthesized 3-substituted indole/2-substituted pyrrole 1,2-dihydropyridine and azaxanthone scaffolds using simple, commercially available starting materials in a one-pot, green, and regioselective manner. Further, the regioselectivity of product formation was confirmed by various studies such as controlled experiments, density functional theory (DFT), Mulliken atomic charge, and electrostatic potential (ESP) surface.

Isolation and biological evaluation 7-hydroxy flavone from L: insights from extensive , DFT, molecular docking and molecular dynamics simulation studies.

The flavonoid based 7-hydroxy flavone (PubChem CID: 5281894; molecular formula: CHO) molecule has been isolated for the first time from the methanolic extract from the leaves of L. in the tropical mangrove ecosystem of Andaman and Nicobar Islands (ANI), India. The molecular structure of bioactive compound was characterized by spectroscopic analysis, including FT-IR, H, C NMR spectroscopy and ESI-HRMS and elucidated as 7-hydroxy flavone.

Biological evaluation of gallic acid and quercetin derived from : insights from extensive and studies.

Gallic acid (PubChem CID: 370) and quercetin (PubChem CID: 5280343) are major phenolic compounds in many mangrove plants that have been related to health cure. In the present study, the active fractions namely gallic acid ( and quercetin ( were isolated from the methanolic extract of leaves of in a Tropical mangrove ecosystem of Andaman and Nicobar Island (ANI), India. The chemical structures were determined by spectroscopic analysis: Fourier-Transform Infrared spectroscopy (FT-IR), H, C Nuclear Magnetic Resonance (NMR) spectroscopy, and High-resolution mass spectrometry (HRMS).

Metal-Free and Regioselective Synthesis of Substituted and Fused Chromenopyrrole Scaffolds the Divergent Reactivity of α-Azido Ketones in Water.

A green and simple approach was developed for the regioselective synthesis of structurally diverse chromenopyrrole frameworks from 3-formylchromones, active methylenes, and α-azido ketones using piperidine as a catalyst in the aqueous medium through a tandem one-pot multicomponent reaction. Further, the synthesized pyrrole framework was successfully converted into biologically significant 6-azaindole derivatives in a simple synthetic transformation. An exciting feature of this synthetic protocol is that the reaction mechanism and formation of the products depend on the nature of the active methylene used.