Publications by authors named "Dhananjaya M Shanthaiah"
Article Synopsis
- The study investigates the prevalence of hirsutism among South-Indian women and establishes modified cut-offs for the modified Ferriman-Gallwey score (mFGS), recognizing the lack of population-specific data for Indian women.
- Conducted with 453 women aged 18-40, the research showed a low prevalence of hirsutism at 1.8% using an mFGS of ≥8, and 9.9% using a cut-off of ≥5.
- The findings suggest a new mFGS cut-off of 5 for South-Indian women to better assess hirsutism prevalence in this population.
Radiological evolution of pituitary hyperplasia in primary hypothyroidism and its differentiation from nonfunctioning pituitary adenoma coexisting with primary hypothyroidism.
Endocrine
October 2024
Article Synopsis
- The study aims to distinguish between isolated pituitary hyperplasia (IPH) and primary hypothyroidism with a nonfunctioning pituitary adenoma (PHCNFPA) in patients with high thyroid stimulating hormone (TSH) levels and sellar masses to prevent unnecessary surgeries.
- Using a retrospective analysis of patients with TSH >50 µIU/ml from 2020-2022, researchers examined MRI results, symptoms, and other clinical data to categorize patients into IPH or PHCNFPA.
- Results indicated a significant age difference between the two groups, with IPH patients presenting at a younger age, while PHCNFPA patients showed more severe symptoms and larger pituitary lesions; unique imaging features helped in differentiating
Article Synopsis
- Thyrotoxicosis is a common condition in endocrine practice, primarily caused by Graves' disease and subacute thyroiditis; differentiating between the two is crucial for proper treatment.
- The study evaluates TSH receptor antibodies (TSHrAb) as a diagnostic tool for distinguishing these conditions in the Indian population, especially since conventional tests like 99mTc thyroid scintigraphy are often unavailable in smaller cities.
- Results show that TSHrAb has a high diagnostic accuracy (AUC: 0.9) compared to other methods, making it a reliable option for distinguishing Graves' disease from subacute thyroiditis.
Vitamin D deficiency or resistance and hypophosphatemia.
Best Pract Res Clin Endocrinol Metab
March 2024
Article Synopsis
- Vitamin D is mostly produced in the skin from sun exposure and is also obtained from food; it's converted into active forms in the liver and kidneys, which are essential for bone health.
- A deficiency in vitamin D, often caused by dietary lack, leads to rickets and osteomalacia, but these conditions can usually be treated with vitamin D supplements.
- Inherited disorders affecting vitamin D metabolism can lead to different types of resistant rickets, characterized by issues like hypophosphatemia, which impairs bone mineralization and can show varying responses to vitamin D supplementation.
Background And Aims: The American Diabetes Association recommends statin therapy for young type 2 diabetes mellitus (T2DM) adults only if one additional cardiovascular (CV) risk factor coexists. The data regarding CV risk factors in young Indian T2DM adults is limited. Hence, we assessed the prevalence of CV risk factors in young adults with T2DM from eastern India.
View Article and Find Full Text PDFBackground: Subcutaneous insulin therapy is associated with important injection site complications, which can influence insulin pharmacokinetics resulting in glycemic fluctuations above and below target levels for blood glucose.
Objective: Our objective was to assess the prevalence and risk factors of cutaneous complications including insulin derived amyloidosis in insulin-injecting diabetes patients and to study the role of ultrasonography (in comparison to gel-assisted palpation) in early diagnosis of lipohypertrophy (LH).
Methods: This was a cross-sectional study conducted at a tertiary care center in India, wherein 500 patients injecting insulin for ≥2 years were randomly enrolled and evaluated for the presence of cutaneous complications of insulin therapy through clinical examination, ultrasonography and punch biopsy of skin.