Publications by authors named "Dhamodharan G"
Article Synopsis
- Multi-target directed ligand-based 2D-QSAR models were created using N-benzyl piperidine derivatives to analyze their inhibitory effects on acetylcholinesterase (AChE) and BACE1, with the dataset including 57 AChE and 53 BACE1 inhibitors.
- Five classes of molecular descriptors were utilized for machine learning approaches like linear methods, genetic function approximation (GFA), support vector machine (SVM), and artificial neural networks (ANN), leading to statistically significant models for both enzymes.
- The models highlighted key molecular descriptors for AChE and BACE1, and nonlinear methods like ANN and SVM outperformed linear approaches, indicating their potential for designing effective anti-Alzheimer's compounds.
The possible protective effect of Solanum nigrum fruit extract (SNFEt) was investigated for its antioxidant and antihyperlipidemic activity against ethanol-induced toxicity in rats. The experimental animals were intoxicated with 20% ethanol (7.9 g/kg/day) for 30 days via gastric intubation.
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