Publications by authors named "Dhakshanya Predheepan"
Cyclophosphamide (CY) exposure is known to affect the ovary and impair fertility. Clinically, treatment is generally given over multiple doses, but research models have generally used single doses. The relative effects of administering multiple small doses of CY in the prepubertal period are not elucidated.
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- Preimplantation embryos can be negatively affected by stress from lab procedures and poor culture conditions, particularly in assisted reproductive technologies.
- This study examined embryos from different-aged mice and found that those from older mothers showed poorer development and higher apoptosis (cell death) when cultured in high oxygen compared to low oxygen environments.
- The results indicate that high oxygen levels are harmful to embryos from older mothers, making them more vulnerable to stress during critical developmental stages, which could impact successful implantation.
Reduced oxygen during embryo culture in human ART prevents embryo oxidative stress. Oxidative stress is also the major mechanism by which maternal diabetes impairs embryonic development. This study employed induced hyperglycemia prepubertal mice to mimic childhood diabetes to understand the effects of varying oxygen tension during in vitro embryonic development.
View Article and Find Full Text PDFReproductive abnormalities in women with a history of childhood diabetes are believed to be partially attributed to hyperglycemia. Prolonged hyperglycemia can negatively affect ovarian function and fertility during reproductive life. To address this in an experimental setting, the present study used streptozotocin-induced hyperglycemic prepubertal mouse model.
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