Novel Ru(II) Complexes as Type-I/-II Photosensitizers for Multimodal Hypoxia-Tolerant Chemo-Photodynamic/Immune Therapy.

Photodynamic therapy (PDT) is increasingly regarded as an attractive approach for cancer treatment due to its advantages of low invasiveness, minimal side effects, and high efficiency. Here, two novel Ru(II) complexes , were designed and synthesized by coordinating phenanthroline and biquinoline ligands with Ru(II) center, and their chemo-photodynamic therapy and immunotherapy were explored. Both and exhibited significant phototoxicity against A549 and 4T1 tumor cells type-I/-II PDT.

Piperidine and bis-piperidine alkaloids from the peels of Areca catechu and their monoamine oxidases inhibitory activity.

Eleven undescribed piperidine alkaloids, arecachines A‒J (1-11), were isolated from the peels of Areca catechu. Compounds 8-11 are featured as bis-piperidine alkaloids. Their structures were elucidated by analysis of UV, IR, HRESIMS, 1D and 2D NMR spectra.

Soil nitrogen biogeochemistry and hydrological characteristics shape the nitrate levels in a river.

The high levels of nitrate (NO) in the surface water have contributed to eutrophication and other eco-environmental damages worldwide. Although the excessive NO concentrations in rivers were often attributed to anthropogenic activities, some undisturbed or slightly disturbed rivers also had high NO levels. This study utilized multi-pronged approaches (i.

Diets supplemented with different solvents extracts of Lepista nuda alters longevity and fecundity, and the expression of related genes in Drosophila melanogaster (Diptera: Drosophilidae).

Exploring the effects of different solvent extracts from Lepista nuda [(Bull. ex Fr.) Cooke] on the lifespan and reproductive capacity of Drosophila melanogaster (Diptera: Drosophilidae), the extracts of the fruiting body and mycelium of L.

Structural and Electronic Modulations of Se-Vacancy-Rich MoSe Triggered by Cr Doping toward Robust Nitrogen Reduction Reaction.

The electrocatalytic nitrogen reduction reaction (NRR) is proposed as an alternative to the Haber-Bosch process, but the development of efficient NRR electrocatalysts remains a challenging task. MoSe has superior conductivity compared to MoS, making it promising in the NRR field. Unfortunately, the scarcity of active sites and competitive hydrogen evolution reaction (HER) hinder its broader applications.

Regional sustainability outranked damming effects in affecting water quality in the lower reaches of the Jinsha River, China.

Besides cascade hydropower development, regional socio-economic activities also significantly affect water quality in the drainage region. However, it remains challenging to ascertain the implications of the damming effects and regional sustainability on water quality. This study examined the variations in water quality indicators, including chemical oxygen demand (COD), ammonia nitrogen (NH-N), and total phosphorus (TP), during the cascade hydropower development (both the construction and impoundment periods from 2006 to 2023) in the lower reaches of the Jinsha River (the upper reaches of the Yangtze River).

Graphene Microflower by Photothermal Marangoni-Induced Fluid Instability for Omnidirectional Broadband Photothermal Conversion.

2-D carbon-based materials are well-known for their broadband absorption properties for efficient solar energy conversion. However, their high reflectivity poses a challenge for achieving efficient omnidirectional light absorption. Inspired by the multilevel structures of the flower, a Graphene Microflower (GM) material with gradient refractive index surface was fabricated on polymer substrates using the UV-intense laser-induced phase explosion technique under the synergistic design of the photothermal Marangoni effect and the fluid instability principle.

Spatial Transcriptomic Approach to Understanding Coronary Atherosclerotic Plaque Stability.

Background: Coronary atherosclerotic plaques susceptible to acute coronary syndrome have traditionally been characterized by their surrounding cellular architecture. However, with the advent of intravascular imaging, novel mechanisms of coronary thrombosis have emerged, challenging our contemporary understanding of acute coronary syndrome. These intriguing findings underscore the necessity for a precise molecular definition of plaque stability.

Oral administration of Robinia pseudoacacia L. flower exosome-like nanoparticles attenuates gastric and small intestinal mucosal ferroptosis caused by hypoxia through inhibiting HIF-1α- and HIF-2α-mediated lipid peroxidation.

The prevention and treatment of gastrointestinal mucosal injury caused by a plateau hypoxic environment is a clinical conundrum due to the unclear mechanism of this syndrome; however, oxidative stress and microbiota dysbiosis may be involved. The Robinia pseudoacacia L. flower, homologous to a functional food, exhibits various pharmacological effects, such as antioxidant, antibacterial, and hemostatic activities.

AMP-activated protein kinase mediates (-)-epigallocatechin-3-gallate (EGCG) to promote lipid synthesis in mastitis cows.

Mastitis, a serious threat to the health and milk production function of dairy cows decreases milk quality. Blood from three healthy cows and three mastitis cows were collected in this study and their transcriptome was sequenced using the Illumina HiSeq platform. Differentially expressed genes (DEGs) were screened according to the |log2FoldChange| > 1 and -value < 0.

Trigonometric Bundling Disulfide Unit Starship Synergizes More Effectively to Promote Cellular Uptake.

A small molecule disulfide unit technology platform based on dynamic thiol exchange chemistry at the cell membrane has the potential for drug delivery. However, the alteration of the CSSC dihedral angle of the disulfide unit caused by diverse substituents directly affects the effectiveness of this technology platform as well as its own chemical stability. The highly stable open-loop relaxed type disulfide unit plays a limited role in drug delivery due to its low dihedral angle.

Pulmonary Fibrosis Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Aberrant Repair.

Rationale: The role of MUC5B mucin expression in IPF pathogenesis is unknown. Bleomycin-exposed rodent models do not exhibit sustained fibrosis or airway remodeling. Unlike mice, ferrets have human-like distribution of MUC5B expressing cell types and natively express the risk-conferring variant that induces high MUC5B expression in humans.

Analysis of the therapeutic effect of synchronous integrated intensity modulated radiotherapy combined with chemotherapy in stage IIIc of cervical cancer.

Objective: To explore the Therapeutic effect of synchronous Integrated intensity modulated radiotherapy combined with chemotherapy in stage IIIc of Cervical Cancer.

Methods: A total of 58 patients with stage IIIC cervical cancer (KPS ≥ 80) were analyzed in this study. They were admitted to our hospital between August 2017 and August 2022.

A syrup containing L-arabinose and D-xylose appears superior to PEG-4000 as a bowel cleansing agent.

Adequate bowel cleansing is crucial for endoscopic diagnosis and treatment, and the recovery of gut microbiota after intestinal cleansing is also important. A hypertonic syrup predominantly comprising L-arabinose and D-xylose (20% xylo-oligosaccharides) can be extracted from the hemicellulose of corn husks and cobs. L-Arabinose and xylo-oligosaccharides have been reported to relieve constipation and improve the gut microbial environment.

Metabolomic analysis of rumen-protected branched-chain amino acids in primiparous dairy cows.

Introduction: Peripartal cows are susceptible to a negative energy balance due to inadequate nutrient intake and high energy requirements for lactation. Improving the energy metabolism of perinatal dairy cows is crucial in increasing production in dairy cows.

Methods: In this study, we investigated the impact of rumen-protected branched-chain amino acid (RPBCAA) on the production performance, energy and lipid metabolism, oxidative stress, and immune function of primiparous dairy cows using metabolomics through a single-factor experiment.

Triterpenoids from the Leaves of and Their PTP1B Inhibitory Activity.

Six new 2-hydroxy ursane triterpenoids, 3---coumaroyloxy-2,19-dihydroxy-12-ursen-28-oic acid (), 3--coumaroyloxy-2,19-dihydroxy-12-ursen-28-oic acid (), 3---coumaroyloxy-2-hydroxy-12-ursen-28-oic acid (), 3--coumaroyloxy-2-hydroxy-12,20(30)-ursadien-28-oic acid (), 3-feruloyloxy-2-hydroxy-12,20(30)-ursadien-28-oic acid (), and 3-feruloyloxy-2-hydroxy-12,20(30)-ursadien-28-oic acid (), along with eleven known triterpenoids (-), were isolated from the leaves of . Their chemical structures were elucidated by comprehensive analysis of UV, IR, HRESIMS, and NMR spectra. All the isolated compounds were evaluated for their PTP1B inhibitory activity.

Electric Field Modeling in Personalizing Transcranial Magnetic Stimulation Interventions.

The modeling of transcranial magnetic stimulation (TMS)-induced electric fields (E-fields) is a versatile technique for evaluating and refining brain targeting and dosing strategies, while also providing insights into dose-response relationships in the brain. This review outlines the methodologies employed to derive E-field estimations, covering TMS physics, modeling assumptions, and aspects of subject-specific head tissue and coil modeling. We also summarize various numerical methods for solving the E-field and their suitability for various applications.

Thyroid-stimulating hormone receptor (TSHR) as a target for imaging differentiated thyroid cancer.

Background: Of the half a million cases of thyroid cancer diagnosed annually, 95% are differentiated thyroid cancers. Although clinical guidelines recommend surgical resection followed by radioactive iodine ablation, loss of sodium-iodine symporter expression causes up to 20% of differentiated thyroid cancers to become radioactive iodine refractory. For patients with radioactive iodine refractory disease, there is an urgent need for new diagnostic and therapeutic approaches.

Fast and accurate computational E-field dosimetry for group-level transcranial magnetic stimulation targeting.

Transcranial magnetic stimulation (TMS) is used to study brain function and treat mental health disorders. During TMS, a coil placed on the scalp induces an E-field in the brain that modulates its activity. TMS is known to stimulate regions that are exposed to a large E-field.

Effects of environmental factors on the river water quality on the Tibetan Plateau: a case study of the Xoirong River, China.

Climate, topography, and landscape patterns affect river water quality through processes that influence non-point source pollution. However, little is known about the response of the water quality of rivers on China's Tibetan Plateau to these environmental factors. Based on the water quality parameters data of the Xoirong River on the Tibetan Plateau in western China, the redundancy analysis and variation partitioning analysis were adopted to determine the main influencing factors affecting river water quality and their spatial scale effects.

Somatostatin Receptor Type 2 and Thyroid-Stimulating Hormone Receptor Expression in Oncocytic Thyroid Neoplasms: Implications for Prognosis and Treatment.

Somatostatin receptor type 2 (SSTR2) and thyroid-stimulating hormone receptor (TSHR) display variable expression in primary thyroid tumors and have been implicated as theranostic targets. This study was designed to explore the differential expression of SSTR2 and TSHR in oncocytic (Hurthle cell) carcinoma (OC) vs oncocytic adenoma (OA). We performed a retrospective review for oncocytic neoplasms treated at our institution from 2012 to 2019.