Molecularly imprinted polymers enhanced peroxidase-like activity of AuNPs for determination of glutathione.

An elaborate composite of molecularly imprinted polymer (MIP)-modified gold nanoparticles (AuNPs)@silica dioxide (SiO) was designed and prepared for real-time colorimetric determination of glutathione (GSH) in serum. Firstly, the MIPs were synthesized on the surface of SiO utilizing GSH as template molecules. Then, AuNPs were synthesized on the surface of MIPs@SiO to produce a composite of MIPs modified by AuNPs@SiO.

Recent Advances in Construction and Application of Metal-Nanozymes in Pharmaceutical Analysis.

Nanozymes, made of emerging nanomaterials, have similar activity to natural enzyme and exhibit promising applications in in the fields of environment, biology and medicine, and food safety science. In recent years, with the deep finding and research to nanozymes by researchers, its application in field of pharmaceutical analysis has emerged gradually, possessing great significance in drug safety evaluation and quality control. This review summarizes the construction of metal nanozymes, strategies to improve their performance and their application in pharmaceutical detection and analysis, especially in detection of target analytes consisting of small molecule medicine macromolecule, toxic and others, which proposes theoretical foundation for development of nanozymes in this field.