Aminated β-Glucan with immunostimulating activities and collagen composite sponge for wound repair.

Immunostimulating activities of yeast β(1 → 3)-D-Glucan (β-Glucan) mainly depended on its structures. However, due to the tight triple helix structure of β-Glucan, its immunostimulating activity is greatly weakened. Therefore, in order to partially unwind the tight triple helix structure of β-glucan and improve its solubility in the medium, we modified it by amination in this study (A-Glu).

Sequentially releasing self-healing hydrogel fabricated with TGFβ3-microspheres and bFGF to facilitate rat alveolar bone defect repair.

Resorption and loss of alveolar bone leads to oral dysfunction and loss of natural or implant teeth. Biomimetic delivery of growth factors based on stem cell recruitment and osteogenic differentiation, as the key steps in natural alveolar bone regenerative process, has been an area of intense research in recent years. A mesoporous self-healing hydrogel (DFH) with basic fibroblast growth factor (bFGF) entrapment and transforming growth factor β3 (TGFβ3) - loaded chitosan microspheres (CMs) was developed.

Recombinant expression a novel fibronectin-collage fusion peptide modulating stem cell stemness via integrin β3.

Constructing bionic extracellular matrix (ECM) is an attractive proposition for tissue engineering and clinical regeneration therapy involving the stemness of stem cells. Here, a novel recombinant protein fibronectin-collagen peptide (FCP) was designed to modulate the function of ECM expressed by Picha. pastoris strain X33.