Heterocycle-Substituted α-Methylene-γ-Butyrolactones Derivatives Synthesis, Antifungal Activity, and 3D-QSAR.

Developing fungicides from active botanical skeletons is one of the effective methods to tackle the resistance of plant pathogens. Based on our previous discoveries, a series of novel α-methylene-γ-butyrolactone (MBL) derivatives containing heterocycles and phenyl rings were designed according to the antifungal molecule carabrone first discovered in plant . The target compounds were synthesized, and the inhibitory activity against pathogenic fungi as well as the mechanism of action were then systematically investigated.

Plant Growth-Promoting Rhizobacteria HN6 Induced the Change and Reorganization of Microflora in the Rhizosphere of Banana Seedlings to Construct a Healthy Banana Microflora.

HN6 was isolated in our previous study and effectively controlled banana wilt. We explored the role of HN6 in constructing a healthy rhizosphere microflora of banana seedlings. The method of antibiotic resistance was used to determine the colonization ability of HN6.

Aureoverticillactam, a Potent Antifungal Macrocyclic Lactam from HN6, Generates Calcium Dyshomeostasis-Induced Cell Apoptosis via the Phospholipase C Pathway in f. sp. Race 4.

Extensive efforts have been made to discover new biofungicides of high efficiency for control of f. sp. race 4, a catastrophic soilborne phytopathogen causing banana Fusarium wilt worldwide.