Dynamic analysis of iris configuration with anterior segment optical coherence tomography.

Purpose: To evaluate dynamic changes in iris configuration and their association with anterior chamber angle width by using anterior segment optical coherence tomography (ASOCT).

Methods: Forty-six normal subjects with open angles and 40 with narrow angles (Shaffer grade < or =2 in three or more quadrants during dark room gonioscopy) were analyzed. The dynamic ASOCT dark-light changes of iris bowing were captured with real-time video recording and nasal iris bowing, nasal anterior chamber angle, and pupil diameter were measured in serial image frames selected from the video capture.

Novel approach for anterior chamber angle analysis: anterior chamber angle detection with edge measurement and identification algorithm (ACADEMIA).

Objective: To describe a novel approach to measuring anterior chamber angle dimensions and configurations.

Methods: Sixty-nine images were selected randomly from the ultrasound biomicroscopic image database to develop the algorithm. Thirty images were selected for further analyses.

Analysis of bleb morphology after trabeculectomy with Visante anterior segment optical coherence tomography.

Background: To describe the use of anterior segment optical coherence tomography (OCT) in imaging intrableb morphology after trabeculectomy.

Methods: 14 post-trabeculectomy eyes from 11 primary open angle glaucoma and 3 primary angle closure glaucoma subjects were studied. The blebs were classified with reference to slit lamp morphology and bleb function.

Association of apolipoprotein E polymorphisms with normal tension glaucoma in a Chinese population.

Purpose: To evaluate the role of apolipoprotein E (APOE) polymorphisms in primary open angle glaucoma (POAG).

Methods: A cohort of 400 unrelated Chinese POAG patients was examined, including 294 cases of high tension glaucoma (HTG) and 106 with normal tension glaucoma (NTG). Also studied were 300 unrelated Chinese control subjects.