Publications by authors named "Dexter Achu Mosoh"
Int J Biol Macromol
November 2024
Article Synopsis
- Focal Adhesive Kinase (FAK) is crucial in aggressive cancers, influencing processes like cancer progression and metastasis, with ongoing challenges in drug resistance and low survival rates for advanced stages, highlighting the need for new treatment options.
- This study utilized a hybrid virtual screening method to identify potential FAK inhibitors by analyzing compounds from the PubChem database, ranking them based on their docking scores and interactions with the FAK catalytic domain.
- The top three promising compounds, along with a known FAK inhibitor, showed consistent stability in molecular dynamics simulations and inhibited the proliferation of A549 cancer cells, indicating their potential as effective cancer treatments, although further validation is necessary.
