Publications by authors named "Dexing Luo"
Article Synopsis
- - Top-down signals related to pain are processed in the ventrolateral periaqueductal gray (vlPAG), and understanding how these signals are regulated can improve our knowledge of pain modulation.
- - In a mouse model with nerve injury, researchers found a specific circuit from the posterior paraventricular thalamic nucleus (PVP) to the rostral zona incerta (ZIr), which then connects to the vlPAG, playing a crucial role in pain hypersensitivity.
- - Disrupting this PVP→ZIr→vlPAG circuit using advanced techniques can reduce pain behaviors, suggesting it could be a new target for treating neuropathic pain.
Article Synopsis
- The study investigates the effects of dexmedetomidine, used during colorectal cancer surgery, on patient survival rates and recurrence-free survival.
- It involved 76 patients, with a comparison between those who received dexmedetomidine and those who did not, showing significant improvements in survival for the dexmedetomidine group.
- The findings suggest that using dexmedetomidine in surgery could enhance long-term outcomes and reduce cancer recurrence for colorectal cancer patients.
Article Synopsis
- The study investigates the differences in how chronic pain affects the brain of male and female rats, highlighting the limited research on sex-specific mechanisms of brain changes related to pain.
- Using advanced imaging techniques, researchers examined the brain structures and functional networks of male and female rats following nerve injury to understand the impact of chronic pain.
- Results showed significant alterations in brain organization and microstructure in male rats, particularly in the hippocampus, while similar effects in female rats were not fully reported, indicating the need for further exploration.
Article Synopsis
- Autism spectrum disorder (ASD) is a challenging neurodevelopmental condition with no effective treatments currently available.
- Dexmedetomidine (DEX), a medication primarily used for sedation, shows potential in improving emotional and cognitive functions, but its impact on ASD symptoms like social deficits needs further investigation.
- In this study, researchers found that DEX improved social behaviors in ASD model mice by affecting IL-6 levels in the brain and identified pathways that may help develop new treatments for ASD.
Thrombolytic therapy or percutaneous coronary intervention for myocardial infarction often cause myocardial ischemia/reperfusion injury (MIRI) and poor prognosis of patients. This study aimed to explore the protective effect and potential mechanism of hydromorphone hydrochloride (HH) on MIRI. Fifty Sprague-Dawley male rats were randomly divided into Sham group, I/R group, HH-pre group, HH-post group, and HH-pre + post group.
View Article and Find Full Text PDFThe disorder of mitochondrial functions plays a key role in oncogenesis. It is known that TSPO (18-kDa translocator protein) lies in a peculiar location at the interface between the mitochondria and the cytosol. TSPO is found in many types of tissues and is associated with multiple cellular processes, including apoptosis, cell proliferation and the regulation of mitochondria.
View Article and Find Full Text PDFBackground: The use of morphine in clinical medicine is severely constrained by tolerance. Therefore, it is essential to examine pharmacological therapies that suppress the development of morphine tolerance. Amiloride suppressed the expression of inflammatory cytokines by inhibiting microglial activation.
View Article and Find Full Text PDFObjectives: Anesthetic drugs had been reported may impact the bio-behavior of the tumor. Propofol and sevoflurane are common anesthetics in the operation for glioblastoma (GBM). This study aims to establish a co-expression prognostic-related genes signature base on propofol and sevoflurane anesthesia to predict prognosis and immunotherapy response in GBM.
View Article and Find Full Text PDFNeuropathic pain is a common dose-limiting side effect of oxaliplatin, which hampers the effective treatment of tumors. Here, we found that upregulation of transcription factor NFATc2 decreased the expression of Beclin-1, a critical molecule in autophagy, in the spinal dorsal horn, and contributed to neuropathic pain following oxaliplatin treatment. Meanwhile, manipulating autophagy levels by intrathecal injection of rapamycin (RAPA) or 3-methyladenine (3-MA) differentially altered mechanical allodynia in oxaliplatin-treated or naïve rats.
View Article and Find Full Text PDFEvidence shows that miRNAs are deeply involved in nervous system diseases, but whether miRNAs contribute to the bortezomib (BTZ)-induced neuropathic pain remains unclear. We aimed to investigate whether miRNAs contribute to bortezomib (BTZ)-induced neuropathic pain and explore the related downstream cascades. The level of miRNAs in the spinal dorsal horn was explored using miRNA microarray and PCR.
View Article and Find Full Text PDFObjective: As an intravenous anesthetic, propofol has been exhibited to provide excellent clinical analgesia. Whether propofol has amelioration property for NP and neuroinflammation remains unexplored. The present study was arranged to probe the role of propofol in the mitigation of NP and neuroinflammation in rats and underlying mechanisms.
View Article and Find Full Text PDFBackground: Although the action mechanism of antineoplastic agents is different, oxaliplatin, paclitaxel, or bortezomib as first-line antineoplastic drugs can induce painful neuropathy. In rodents, mechanical allodynia is a common phenotype of painful neuropathy for 3 chemotherapeutics. However, whether there is a common molecular involved in the different chemotherapeutics-induced painful peripheral neuropathy remains unclear.
View Article and Find Full Text PDF