CX3CL1 rs170364 gene polymorphism has a protective effect against major depression by enhancing its transcriptional activity.

Studies have shown that adult hippocampal neurogenesis may be a cause of depression. CX3CL1 is a chemokine that plays an important role in adult neurogenesis. This study aimed to investigate the relationship between CX3CL1 polymorphisms (rs170364) and the risk of depression.

[Clinical manifestation of Kaposi sarcoma in otorhinolaryngology head and neck surgery].

Objective: To improve the knowledge of Kaposi sarcoma and the relationship between Kaposi sarcoma and human immunodeficiency virus (HIV) infection, and to improve the ability to diagnose and treat Kaposi sarcoma and acquired immune deficiency syndrome (AIDS).

Methods: Symptoms, signs and results of 121 patients encountered in the department of otorhinolaryngology head and neck surgery in Tanzania, who was diagnosed as Kaposi sarcoma actually with HIV infection and AIDS, were retrospectively analyzed in this study.

Results: There were 46 males and 75 females with age ranged from 5 to 65 years, medium 30 year.

[Establishment of an artificial neural network model for analysis of the influence of climate factors on the density of Aedes albopictus].

Objective: To establish a model for predicting the density of Aedes albopictus based on the climate factors.

Methods: The data of Aedes albopictus density and climate changes from 1995 to 2001 in Guangzhou were collected and analyzed. The predicting model for Aedes albopictus density was established using the Artificial Neural Network Toolbox of Matlab 7.

A randomized controlled trial of low-dose recombinant human interferons alpha-2b nasal spray to prevent acute viral respiratory infections in military recruits.

The military population has a high disease burden of acute viral respiratory infections in China. To assess the efficacy and safety of a low-dose recombinant human interferon alpha-2b (rIFNalpha-2b) nasal spray in preventing acute viral respiratory infections in military population, we performed this randomized controlled trial. The results showed that application of the rIFNalpha-2b nasal spray had the benefits in prevention of infections caused by influenza A virus, influenza B virus parainfluenza viruses 1-3 and adenovirus species B.

[An epidemiological investigation of bats carrying SARS-CoV in Guangzhou and its vicinity].

Objective: To detect serve acute respiratory syndrome-associated coronavirus (SARS-CoV) and SARS-like-CoV in fruit bats captured in Guangzhou and its vicinity.

Methods: Totally 927 bats of 9 species (Cynopterus sphinx, Rousettus leschenaulti, Miniopterus schreibersi, Hipposideros pratti, Rhinolophusasinicus, Scotophilusakuhlii, Hipposideros Pomona, Rhinolophus affinis, and Rhinolophus pusillus) captured in Guangzhou and its vicinity from September 2004 to November 2005 were available for this investigation, from which 3,043 samples (813 throat swasb, 524 sera, 853 lung tissues and 853 colorectal tissue specimens) were obtained. SARS-Cov and SARS-like-CoV were detected in these specimens using diagnostic kit for novel coronavirus N protein (ELISA), SARS-CoV Virus RNA detection kit, fluorescence PCR, Genchip, RT-PCR and cell isolation culture methods.

[A field trial of recombinant human interferon alpha-2b for nasal spray to prevent SARS and other respiratory viral infections].

Objective: To study the preventive effect of recombinant human interferon alpha-2b for nasal spray against SARS and other common respiratory viral infections by serum-epidemiological method.

Methods: A randomized, placebo-controlled, double-blind field trial study in populations with 14,391 persons from SARS prevalent cities or provinces in China during May-Jun, 2003 and Dec-Apr, 2004. Interferon alpha-2b was given twice per day, once 9 x 10(5) IU by nasal spray for 5 days.

[A field trial for evaluating the safety of recombinant human interferon alpha-2b for nasal spray].

Objective: To evaluate the safety of recombinant human interferon alpha-2b for nasal spray for the prevention of SARS and other upper respiratory viral infections.

Methods: Field epidemiologic evaluation was conducted, the design was randomized and had a synchronously parallel control group. In the study, the drugs were given for five days and all subjects were followed up for ten days.

[Epidemiological study of the features of the index cases in SARS case clusters].

Objective: To understand the epidemiological characteristics of the index cases in severe acute respiratory syndrome (SARS) cases clusters and to evaluate their importance in the whole epidemic process of SARS.

Methods: Data of the index SARS cases and the subsequent case clusters were collected by means of face-to-face interview in combination with field investigation and case history consultations.

Results: In all three SARS clusters, the index cases all had chronic disease and played the role of infection source that transmitted the virus to the patients' family members, attending medical staff as well as other non-SARS patients sharing the same ward with them.