Impact of Mental Health First Aid Training Courses on Patients' Mental Health.

Background: With the prevalence of mental issues worldwide, more and more people are suffering from psychological torture. Mental Health Gap Action Program (mhGAP) has been introduced to improve the life quality of humans.

Objectives: To explore and synthesize evidence of participants' experience of mental health first aid (MHFA) training course.

Bacillus subtilis plays a role in the inhibition of transporter ABCB1 in Caco-2 cells.

Backgrounds: The mechanism of drug-resistant epilepsy has been incompletely understood, and the transporter hypothesis is one of the most cited theories. The association between gut microbiome and epilepsy is increasingly recognized but the mechanism remains unclear. We hypothesize that gut microbiome plays a role of pharmacokinetics of antiseizure medicines (ASMs) through transporters at the host-microbe interface.

Inhibitory role of lentivirus-mediated aquaporin-4 gene silencing in the formation of glial scar in a rat model of traumatic brain injury.

Traumatic brain injury (TBI), an acute degenerative pathology of the central nervous system, is a leading cause of death and disability. As the glial scar is a mechanical barrier to nerve regeneration, inhibitory molecules in the forming scar and methods to overcome them have suggested molecular modification strategies to allow neuronal growth and functional regeneration. Herein, we aim to investigate the effects of aquaporin-4 (AQP4) gene silencing on the glial scar formation after TBI by establishing rat models.