Publications by authors named "Dewaeles E"
Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various solid cancers. However, its clinical effectiveness is strongly limited by frequent severe adverse effects, in particular nephrotoxicity and chemotherapy-induced peripheral neuropathy. Thus, there is an urgent medical need to identify novel strategies that limit cisplatin-induced toxicity.
View Article and Find Full Text PDFCadmium is an environmental pollutant well known for its nephrotoxic effects. Nevertheless, mechanisms underlying nephrotoxicity continue to be elucidated. MicroRNAs (miRNAs) have emerged in recent years as modulators of xenobiotic-induced toxicity.
View Article and Find Full Text PDFPurpose: Cisplatin-induced acute kidney injury (CIA) is a serious adverse event that affects 20-40% of exposed patients, despite any implemented precaution to avoid it. The aim of this work was therefore to identify a relevant nephroprotective method for CIA.
Methods: We searched Pubmed, Embase, and Web of Science from 1 January 1978 to 1 June 2018, without language restriction.
Article Synopsis
- New treatments for idiopathic pulmonary fibrosis (IPF) are needed due to the lack of effective options, with a focus on understanding lung fibroblast activation, the main factor in fibrosis.
- The study identifies DNM3OS, a long noncoding RNA, as a crucial regulator of TGF-β-induced differentiation of lung fibroblasts into myofibroblasts, which contributes to fibrosis.
- Targeting DNM3OS and its associated microRNAs showed promise in preventing and even reversing pulmonary fibrosis, highlighting potential new therapeutic strategies for IPF.
Although Tacrolimus is an immunosuppressive drug widely used in renal transplantation, its chronic use paradoxically induces nephrotoxic effects, in particular renal fibrosis, which is responsible for chronic allograft dysfunction and represents a major prognostic factor of allograft survival. As molecular pathways and mechanisms involved in Tacrolimus-induced fibrogenic response are poorly elucidated, we assessed whether miRNAs are involved in the nephrotoxic effects mediated by Tacrolimus. Treatment of CD-1 mice with Tacrolimus (1 mg/kg/d for 28 days) resulted in kidney injury and was associated with alteration of a gene expression signature associated with cellular stress, fibrosis and inflammation.
View Article and Find Full Text PDFBackground And Aims: Immune tolerance breakdown during UC involves the peroxisome proliferator-activated receptor-γ (PPARγ), a key factor in mucosal homoeostasis and the therapeutic target of 5-aminosalycilates, which expression is impaired during UC. Here we assess the impact of glucocorticoids (GCs) on PPARγ expression, focusing especially on extra-adrenal cortisol production by colonic epithelial cells (CECs).
Methods: Activation of PPARγ in the colon was evaluated using transgenic mice for the luciferase gene under PPAR control (peroxisome proliferator response element-luciferase mice).
Article Synopsis
- miRNAs are crucial for normal cell function, and their deregulation is linked to various complex diseases, including fibrotic lung diseases like idiopathic pulmonary fibrosis (IPF).
- Recent research identified miR-199a-5p as a significant miRNA involved in lung fibrosis, showing increased levels in both mouse models and IPF patients.
- miR-199a-5p promotes the activation and pathogenic properties of lung fibroblasts and plays a vital role in TGFβ signaling, indicating its potential as a target for new therapeutic strategies against fibrosis in the lungs and other organs.