Publications by authors named "Dewa G Ugrasena"
Xenobiotic and folate metabolic pathways are important for the maintenance of genetic stability and may influence susceptibility to the development of childhood acute lymphoblastic leukaemia (ALL). In this study, we investigated 10 polymorphisms in 6 genes (GSTM1-present/null, GSTT1-present/null, GSTP1 1578A > G, NQO1 609C > T, MTHFR 677C > T, MTHFR 1298A > C, MTHFD1 1958G > A, 3'-TYMS 1494 6bp-deletion/insertion, 5'-TYMS 28bp-tandem repeats, and SLC19A1 80G > A) in a cohort of 185 Javanese children with ALL and 177 healthy controls. In ALL patients, none of the polymorphisms demonstrated a statistically significant association with ALL after correcting for multiple comparisons.
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- Genetic variations in the TSER enhancer region and MTHFR C677T polymorphism can affect how sensitive individuals are to methotrexate, a common chemotherapy drug.
- A study compared these genetic polymorphisms in children with acute lymphoblastic leukaemia (ALL) in Indonesia and the Netherlands.
- The findings showed distinct differences in genotype frequencies between the two populations, suggesting that treatment approaches for Indonesian children with ALL may need to consider these genetic factors.