Publications by authors named "Devyn Yates"
is the agent of onchocerciasis (river blindness) and targeted by WHO for elimination though mass drug administration with ivermectin. A small percentage of adult worms develop pleomorphic neoplasms (PN) that are positively associated with the frequency of ivermectin treatment. Worms with PN have a lower life expectancy and a better understanding about the proteins expressed in PN, and how PN affect protein expression in different tissues could help to elucidate the mechanisms of macrofilaricidal activity of ivermectin.
View Article and Find Full Text PDFA novel antigen biomarker for detection of high-level of Loa loa microfilaremia.
PLoS Negl Trop Dis
September 2024
Article Synopsis
- Loiasis is a disease caused by the Loa loa nematode, which can lead to serious side effects in people with high levels of the parasite after treatment with ivermectin, complicating elimination efforts for lymphatic filariasis and onchocerciasis in Central Africa.
- Researchers developed a new antigen capture ELISA test to detect a specific protein, Ll-Bhp-1, in loiasis patients, finding it present in 63.8% of samples and strongly correlated with high parasite counts.
- This Ll-Bhp-1 antigen test is both specific to loiasis and effective at identifying patients at high risk for adverse reactions to ivermectin, thereby aiding in disease mapping and elimination programs in the affected regions.
Paragonimiasis is a zoonotic, food-borne trematode infection that affects 21 million people globally. Trematodes interact with their hosts via extracellular vesicles (EV) that carry protein and RNA cargo. We analyzed EV in excretory-secretory products (ESP) released by Paragonimus kellicotti adult worms cultured in vitro (EV ESP) and EV isolated from lung cyst fluid (EV CFP) recovered from infected gerbils.
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