Publications by authors named "Devyn Thorne"
Article Synopsis
- Coronaviruses can originate from animals and cause serious illnesses in both humans and animals, with a key protein called Mac1 playing a role in viral replication and interferon inhibition.
- Researchers discovered a compound, MCD-628, that inhibits Mac1 but found its effectiveness was limited due to poor permeability.
- By creating more hydrophobic derivatives, they identified four compounds that successfully inhibited Mac1 and reduced replication of coronaviruses, confirming their specificity through drug-resistance mutations, but this resistance came at a cost to the virus's overall fitness.
Characterizations of angiotensin-converting enzyme-2 (ACE2) peptidase activity.
Arch Biochem Biophys
November 2024
Angiotensin (Ang) II (1-8) is a potent vasoconstrictor known for its role in hypertension. Angiotensin-converting enzyme (ACE2) converts Ang II (1-8) to a vasodilator Ang (1-7) by removing the carboxy-terminal Phe. ACE2 more recently gained attention as the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the coronavirus disease 2019 (COVID-19) pandemic.
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