STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and T1 differentiation.

Stromal interaction molecule 1 (STIM1) is critical for store-operated Ca entry (SOCE) and T cell activation. T helper 1 (T1) cells, which express T-bet (encoded by TBX21), mediate immunity to intracellular pathogens. Although SOCE is known to regulate other T lineages, its role in Th1 differentiation remains unclear.