Nature of the Nickel-Halogen Bond in NiX Compounds (X = F, Cl, Br, I): A Multireference Configuration Interaction and Ab Initio Valence Bond Study.

In a recent study ( , , 11812-11820), gas-phase cationic NiX compounds (X = F, Cl, Br, and I) were probed by nickel L-edge XAS, from which it was concluded that NiF was best described as an ionic [NiF] complex while the remaining three compounds were described as covalent Ni(3d) species ( depicts a ligand-based hole). An abrupt transition from a classical to an inverted ligand field was suggested as responsible for the change in ground-state electronic structures. Herein, the NiX series is investigated by using MRCI and ab initio VB calculations.

Long-term hypoxia modulates depolarization activation of BK currents in fetal sheep middle cerebral arterial myocytes.

Introduction: Previous evidence indicates that gestational hypoxia disrupts cerebrovascular development, increasing the risk of intracranial hemorrhage and stroke in the newborn. Due to the role of cytosolic Ca in regulating vascular smooth muscle (VSM) tone and fetal cerebrovascular blood flow, understanding Ca signals can offer insight into the pathophysiological disruptions taking place in hypoxia-related perinatal cerebrovascular disease. This study aimed to determine the extent to which gestational hypoxia disrupts local Ca sparks and whole-cell Ca signals and coupling with BK channel activity.