Publications by authors named "Devin Palmer"
Article Synopsis
- Nearly one-third of patients with epilepsy experience seizures that do not respond to standard anti-seizure medications, prompting research into alternative treatments.
- This study focused on the deep and intermediate layers of the superior colliculus (DLSC) in adult WAG/Rij rats to investigate how modulating DLSC activity impacts seizure occurrence, utilizing both continuous and closed-loop optogenetic stimulation methods.
- Results showed that while continuous DLSC stimulation reduced seizures in male rats, closed-loop neuromodulation proved effective for both males and females, indicating differing responses to stimulation based on sex.
The WAG/Rij strain of rats is commonly used as a preclinical model of genetic absence epilepsy. While widely utilized, the developmental trajectory of absence seizure expression has been only partially described. Moreover, sex differences in this strain have been under-explored.
View Article and Find Full Text PDFSoman (GD) exposure results in status epilepticus (SE) that leads to neurodegeneration, neuroinflammation, and behavioral consequences including learning and memory deficits. The neuroinflammatory response is characterized by the upregulation of the pro-inflammatory cytokine, interleukin-1 (IL-1), which mediates the expression of other neurotoxic cytokines induced after GD exposure. However, the specific role of IL-1 signaling has not been defined in terms of the consequences of GD-induced SE.
View Article and Find Full Text PDF