Publications by authors named "Devin A Simpkins"
The gut microbiota is important for host health and immune system function. Moreover autoimmune diseases, such as rheumatoid arthritis, are associated with significant gut microbiota dysbiosis, although the causes and consequences of this are not fully understood. It has become clear that the composition and metabolic outputs of the microbiome exhibit robust 24 h oscillations, a result of daily variation in timing of food intake as well as rhythmic circadian clock function in the gut.
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- - Chronic inflammation, such as that seen in rheumatoid arthritis, leads to rhythmic joint inflammation and alters energy metabolism in muscles and the liver at different times of the day.
- - Research using a mouse model indicates that inflammatory conditions trigger changes in gene expression and fat metabolism, particularly through mechanisms involving EGFR-JAK-STAT3 signaling.
- - The study found an increase in ceramides and sphingolipid production, especially during the day when inflammation peaks, highlighting a connection between inflammation timing and lipid metabolism issues.