Publications by authors named "Devika Rana"
Article Synopsis
- Malaria, caused by Plasmodium species, poses a serious health threat in tropical regions, with increasing resistance to existing treatments prompting the need for new drug development.
- Falcipains, a group of cysteine proteases that play a key role in the parasite's heme metabolism during its life cycle in red blood cells, have been identified as promising targets for new therapies.
- This discussion reviews the biology and chemistry of falcipains, highlighting efforts to create effective inhibitors and examining why some compounds succeed while others fail in targeting these important proteins for antimalarial treatment.
Falcipains (FPs), cysteine proteases in the malarial parasite, are emerging as the promising antimalarial drug targets. In order to identify novel FP inhibitors, we generated a pharmacophore derived from the reported co-crystal structures of inhibitors of Plasmodium falciparum Falcipain-3 to screen the ZINC library. Further, the filters were applied for dock score, drug-like characters, and clustering of similar structures.
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