Publications by authors named "Devika Raj"

Cubosomes are novel vesicular drug delivery systems with lipidic liquid crystal nanoparticles formed of predetermined proportions of amphiphilic lipids. They have a honeycomb-like structure and are thermodynamically stable. These bicontinuous lipid layers are separated into two water-based channels internally that can be used by various bioactive substances, including drugs, proteins, and peptides.

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The emergence of microorganisms with resistance toward antibiotics has been widely recognized as a growing hazard to public health. Here, we report the whole genome sequence of strain THK which was isolated from an aquaculture farm in Kerala, India. Standard disc diffusion and strip methods were used for antibiotic susceptibility testing and minimum inhibitory concentration detection.

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Photodynamic antimicrobial chemotherapy (PACT), employing a combination of light and natural photosensitizer molecules such as curcumin, has been accepted as a safe modality for removing aquatic pathogens which cause diseases such as cholera in humans and vibriosis in aquatic animals. Curcumin and its photodegradation products are generally considered as safe to animals, but the impact of reactive oxygen species (ROS) generated by these products on the growth and survival of organisms at a cellular level has not been studied in detail. The ROS generated by curcumin on photoexcitation using blue light (λ 405 nm, 10 mW cm) disinfects more than 80% of free-living spp.

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The draft genome sequence of Shewanella indica strain MMRF542, which was isolated from a marine sponge (Callyspongia diffusa), is reported. The genome sequence provides insight into the ecological relevance and biotechnological potential of species.

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Article Synopsis
  • Melanin, a versatile biopolymer, has various applications including toxic chemical recovery from water and biomedical imaging, with a focus on a type called pyomelanin secreted by the sponge-associated bacterium Shewanella sp.
  • The study describes the structural properties and biosynthetic pathway of Shewanella-melanin, revealing its effective ability to bind and recover metals like manganese and iron from liquid media.
  • The findings suggest that Shewanella-melanin could serve as a sustainable solution for removing toxic pollutants from water, aligning with the sustainable development goal of ensuring clean water access.
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We report the draft genome sequence of ASBT-1, a representative of sequence type 155 (ST155), obtained from India. Considering the known wide variety of pathogenic and antibiotic resistance potentials, this strain should be of great interest for detailed comparative genomic analysis.

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