Publications by authors named "Devi Wahyuningtyas"
Polyglutamine-Specific Gold Nanoparticle Complex Alleviates Mutant Huntingtin-Induced Toxicity.
ACS Appl Mater Interfaces
December 2021
Article Synopsis
- Huntington's disease (HD) is linked to the toxic aggregation of a mutated protein called huntingtin (mHtt), which causes neuronal dysfunction.
- Researchers developed a specific gold nanoparticle (AuNP) complex that targets and reduces the toxicity of mHtt by using a specially designed peptide, JLD1, that binds to the toxic aggregates.
- The modified AuNPs (AuNPs-JLD1-PEI) can enter cells, break down mHtt inclusions, and have shown promising results in a larval model of HD, indicating potential new treatments for this disease.
Huntington's disease (HD) is classified as a protein-misfolding disease correlated with the mutant Huntingtin (mHtt) protein with abnormally expanded polyglutamine (polyQ) domains. Because no effective drugs have yet been reported, attempts to develop better therapy to delay the age of onset are in urgent demand. In this study, an amphiphilic peptide consisting of negatively charged hexaglutamic acid and a stretch of decaglutamine (E Q ) was chemically synthesized as an inhibitor against polyQ and mHtt toxicity.
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