Embracing Uncertainty: How literary writing helps us change our minds.

Creative writing and cognitive neuroscience can jointly illuminate how literary writing can change our minds by enhancing our tolerance for uncertainty. From my perspective as a novelist, I will show how literary writing hijacks the mechanisms of day-to-day perception and orchestrates cognition to facilitate vividness of (imaginary) experience and insight. Drawing on examples from my novel and other research, I will discuss the role of uncertainty and literary devices such as contradiction and paradox in stymieing habitual assumptions while inviting the reader's sensory imagination and conscious awareness, thereby creating an open space for insight.

Effects of a water-based program on women 65 years and over: a randomised controlled trial.

The purpose of this study was to assess the effects of a water-based exercise and self-management program on balance, fear of falling, and quality of life in community-dwelling women 65 years of age or older with a diagnosis of osteopenia or osteoporosis. Fifty women with an average age of 73.3 years (range 65.

Pharmacokinetics and tissue distribution of the nonadecapeptide Moli1901 in rats and mice.

1. Administration of aerosolized, radiolabelled Moli1901 (duramycin, 2622U90), a 19 amino acid polycyclic peptide, to rats resulted in the deposition of high amounts of radiolabel in the respiratory tract, with deposited radiolabel persisting almost unchanged through 7 days after dosing. Little to no radiolabel was present in the bloodstream of these rats.

Pharmacokinetics, disposition and metabolism of 546C88 (L-NG-methylarginine hydrochloride) in rat and dog.

1. 14C-546C88 (14C-L-NG-methylarginine hydrochloride) was administered to rat and dog as a single 5-min intravenous infusion at 1.7 mg/kg (20 mg/kg/h) to aid in the preclinical safety evaluation of the compound.

The comparative disposition of [14C]-fotemustine in non-tumourous and tumourous mice.

The distribution and excretion of radioactivity from [14C]-fotemustine was examined in mice with melanomas at different stages of development to determine whether the disease state substantially alters the disposition of the drug and its metabolites. Normal BDF1 mice and mice that had been subcutaneously grafted with B16 melanoma either 1, 3, 7, 14 or 21 days previously were used. The animals were killed at either 5 min, or at 3, 24 or 96 h after receiving an intravenous dose of [14C]-fotemustine (20 mg/kg) and were examined either by whole-body autoradiography or by liquid scintillation counting of excreta and tissues of interest.