Publications by authors named "Devendra K Vora"
Article Synopsis
- Oxidized phospholipids, like OxPAPC, contribute to inflammation in endothelial cells by inducing chemokines like IL-8 and causing cholesterol depletion, leading to altered cellular signaling.
- Cholesterol depletion activates the sterol regulatory element-binding protein (SREBP), which enhances the production of IL-8 by binding to its promoter and is linked to changes in cholesterol levels.
- The study implies that the relationship between cholesterol levels and SREBP activation may play a significant role in the inflammation associated with atherosclerosis.
Objective: Previous studies have demonstrated the importance of endothelial apical expression of connecting segment-1 (CS-1) fibronectin in mediating the entry of monocytes into atherosclerotic lesions and other sites of chronic inflammation. We previously demonstrated that oxidized PAPC (OxPAPC) increases monocyte-specific binding to arterial endothelium by causing deposition of CS-1 fibronectin on apical alpha5beta1 integrin. The present studies identify important signal transduction components regulating this pathway.
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