BRCA1 expression in leukoplakia and carcinoma of the tongue.

Background And Objectives: Expression of BRCA1 was examined in patients with leukoplakia and carcinoma of the tongue. Its prognostic value was evaluated in patients with tongue cancer.

Methods: Expression of BRCA1 was studied by immunohistochemical localization.

Role of Dietary Intake and Biomarkers in Risk of Breast Cancer: A Case Control Study.

Reproductive factors are not considered to play a significant role in the aetiology of breast cancer in low incidence regions like Gujarat, although it is well established that they exert a major influence on such tumours in the western developed world. Women in the western Indian region have a very low prevalence of smoking, alcohol consumption but a high prevalence of vegetarianism. Noting the changes in the life style practices with increasing affluence is likely to yield several interesting findings in such a population.

A Study of Various Sociodemographic Factors and Plasma Vitamin Levels in Oral and Pharyngeal Cancer in Gujarat, India.

Present study examined various socio-demographic factors, dietary patterns, habit of tobacco consumption and plasma vitamin levels in 56 healthy individuals, 146 patients with oral precancerous conditions (OPC) and 132 untreated oral and pharyngeal cancer patients. The subjects were interviewed with a detailed health, habit and diet questionnaire. Plasma b-carotene, vitamin-A and vitamin-E levels were determined spectrophotometrically.

Vitamin B(12) and Folate Status in Head and Neck Cancer.

Deficiency of vitamin B(12) and folate is associated with causation of certain precancerous conditions and cancer. The present study was carried out on 56 controls, 167 patients with oral precancerous conditions (OPC) and 214 head and neck cancer patients, to evaluate the plasma vitamin B(12) and folate levels to determine their association with tobacco habits and vegetarianism and several sociodemographic factors. The subjects were interviewed using a health habit and diet questionnaire at the time of blood collection.

Prognostic significance of biomarkers in squamous cell carcinoma of the tongue: multivariate analysis.

Background And Objectives: Expression of a panel of biomarkers, such as p53, Bcl-2, Cyclin D1, c-myc, p21ras, c-erb B2, cytokeratin-19 (CK-19), and factor VIII-related antigen (FVIII-RA), was studied together in anterior tongue tumors from the oral cavity and in posterior tongue tumors from the oropharynx of patients with early- and locally advanced-stage disease, to evaluate their prognostic value.

Methods: The expression of the above-mentioned biomarkers was studied by immunohistochemical localization.

Results: In this study, 18%, 26%, 62%, 75%, 73%, 50%, and 29% of the tumors exhibited p53, Bcl-2, Cyclin D1, c-myc, p21ras, c-erb B2, and CK-19 expression, respectively.

Clinical usefulness of telomerase activation and telomere length in head and neck cancer.

Background: Telomere shortening at every replication cycle is postulated to limit the life span of human somatic cells. In contrast, activation of telomerase is proposed to be an essential step for cancer cell immortalization. Head and neck cancer is the most common malignancy in the Indian population compared with Western countries.

Solitary extramedullary plasmacytoma - larynx.

Solitary Plasmacytoma of the larynx is a rare tumor with male predominance and most patients are between 50-70 years of age. The paper reports a case of Solitary Extramedullary' Ipasmacytoma. (EMP) ljirynx in subglottic region, in a 65-year-old man successfully treated with complete response to radiotherapy.

Primary malignant large bowel lymphoma.

Primary gastrointestinal (GI) lymphomas constitute about 5.6 per cent of total gut neoplasms. The involvement of large bowel as primary site is all the more rare.