Interaction of Graphene Oxide Particles and Dendrimers with Human Breast Cancer Cells by Real-Time Microscopy.

Graphene oxide (GOX) has become attractive due to its unique physicochemical properties. This nanomaterial can associate with other dendrimers, making them more soluble and allowing better interaction with biomacromolecules. The present study aimed to investigate, by real-time microscopy, the behavior of human breast cancer cells exposed to particles of materials based on graphene oxide.

A modified hybrid silsesquioxane/histidine composite for copper and zinc adsorption and it behavior in the electro-oxidation of ascorbic acid.

Octa-(3-chloropropryl)silsesquioxane was chemically modified with histidine (SSQ-H) and characterized by spectroscopy in the infrared region (FT-IR), X-ray diffraction (XRD), X-ray Dispersive Energy Spectroscopy (EDX), Scanning Electron Microscopy (SEM). The analytical properties of SSQ-H were tested regarding of Cu and Zn adsorption and as an electrochemical sensor for the detection of ascorbic acid. The metal sorption results indicate that maximum amount of Cu and Zn adsorbed (Nf) were 1.

Effect of a nanostructured dendrimer-naloxonazine complex on endogenous opioid peptides μ1 receptor-mediated post-ictal antinociception.

Unlabelled: The aim of this study was to investigate the capacity of the host dendrimer DAB-Am-16 as a drug carrier to reduce the time required for the encapsulated naloxonaxine to establish an irreversible covalent bond with μ(1)-opioid receptor (resulting in a pharmacologically selective effect). The efficacy of dendrimer-naloxonazine nanocomplex (DNC) was studied in antinociception induced by convulsions elicited by intraperitoneal (IP) administration of pentylenetetrazole, and analgesia was measured by the tail-flick test. We found that animals showed increased tail-flick latencies following convulsions.

Study of an organically modified clay: selective adsorption of heavy metal ions and voltammetric determination of mercury(II).

In this work, a hydrophilic clay, Na-montmorillonite from Wyoming, USA, was rendered organophilic by exchanging the inorganic interlayer cations for hexadecyltrimethylammonium ions (HDTA), with the formulae of [(CH(3))(3)N(C(16)H(33))](+) ion. Based on fact that organo-clay has high affinities for non-ionic organic molecules, 1,3,4-thiadiazole-2,5-dithiol was loaded on the HDTA-montmorillonite surface, resulting in the 1,3,4-thiadiazole-2,5-dithiol-HDTA-montmorillonite complex (TDD-organo-clay). The following properties of TDD-organo-clay are discussed: selective adsorption of heavy metal ions measured by batch and chromatographic column techniques, and utilization as preconcentration agent in a chemically modified carbon paste electrode (CMCPE) for determination of mercury(II).