Decadal Trends and Associated Factors of Colorectal Cancer in Kerala Between 2010 and 2021 Among Patients in a Tertiary Hospital-Based Cancer Registry.

Introduction The incidence of colorectal cancer (CRC) has notably risen on a global scale, owing to modifications in lifestyle patterns and the overconsumption of processed food to meet nutritional requirements. Colorectal cancer is among the most common cancers in India, with a significant number of new cases reported annually. The aim of our study is to examine the trends and association of CRC in Kerala between the years 2010-2021 among patients reporting at a tertiary Hospital-Based Cancer Registry (HBCR) in Ernakulam.

Diosmin induces mitochondrial-mediated apoptosis and anti-inflammatory effects in Hep-2 cells: an integrated in vitro and in silico analysis.

The present study aims to explore the anticancer efficacy of Diosmin by inducing mitochondrial-mediated apoptosis in human epidermoid carcinoma cells (Hep-2). This is done by cell line assays and studying crucial inflammatory and apoptotic signaling molecules. The cytotoxicity property of Diosmin was evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.

Impact of selenium supplementation on antioxidant enzyme activity and liver gene expression in juvenile pangasius catfish (Pangasius pangasius).

This study examined the effect of dietary selenium (Se) fortification on growth efficiency, antioxidant status, and liver gene expression in juvenile pangasius catfish. Sodium selenite was incorporated into a basal diet at incremental levels of 0-2.0 mg Se/kg.

Guided intentional replantation of a mandibular premolar with type IIIIb dens invaginatus associated with peri-invagination periodontitis without root canal treatment- A case report.

Aim: This report highlights successful management of a rare case of a mandibular premolar with Oehler's Type IIIb Dens Invaginatus (DI) and peri-invagination periodontitis with guided intentional replantation (IR) without root canal treatment.

Methods: A 22-year-old female patient reported with discomfort and a sinus tract associated with tooth #21. Clinical examination and cone beam computed tomography revealed tooth #21 had an Oehler's Type IIIb DI with peri-invagination periodontitis.

Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study.

Background: Periodontitis and diabetes are chronic diseases where inflammation plays a central role, with each condition exacerbating the other. Pyroptosis, an inflammatory form of programmed cell death, is implicated in periodontitis and diabetes. The activation of gasdermin D (GSDMD), a key mediator of pyroptosis, promotes cytokine release and perpetuates tissue destruction in both.

Gingival tissue evaluation using soft tissue-cone-beam computed tomography and root coverage esthetic score in the treatment of isolated gingival recession: A clinical study.

Objectives: Comparative assessment of the effectiveness of coronally advanced flap (CAF) with subepithelial connective tissue graft (SCTG) and the envelope technique with SCTG in Miller's Class I recession utilizing soft tissue-cone-beam computed tomography (ST-CBCT) and root coverage esthetic score (RES).

Materials And Methods: Twenty patients were randomly assigned to Group I (CAF + SCTG) and Group II (envelope technique + SCTG) using the coin toss method, with 10 patients in each group. Recession height (RH) and width (RW), probing pocket depth (PD), clinical attachment level (CAL), and keratinized tissue height (HKT) were assessed at baseline and 6 months.

Classification of direct threats to the conservation of ecosystems and species 4.0.

Identifying and assessing the magnitude of direct threats to ecosystems and species are critical steps to prioritizing, planning, implementing, and assessing conservation actions. Just as medical clinicians and researchers need a standard way to talk about human diseases, conservation practitioners and scientists need a common and comprehensive language to talk about the threats they are facing to facilitate joint action, evaluation, and learning. To meet this need, in 2008 the IUCN Species Survival Commission and the Conservation Measures Partnership produced the first version of a common threats classification with the understanding that it would be periodically updated to take into account new information and learning.

Effect of Virtual Reality Distraction Method on the Level of Salivary Cortisol in Children With Autism Spectrum Disorder During Dental Treatment.

To examine the effect of using Virtual Reality distraction on salivary cortisol levels in children with Autism Spectrum Disorders (ASD) during routine dental treatments. A randomized cross-over study was designed and children with a known diagnosis of ASD, between 8 and 15 years of age, requiring routine, non-invasive dental treatments, were recruited. They were divided into 2 groups (group 1 and group 2) and scheduled for dental treatments using conventional behavior management and/or VR distraction techniques in their first and second dental visit, accordingly.

Secondary nucleation guided noncovalent synthesis of dendritic homochiral superstructures via growth on and from surface.

Secondary nucleation is an emerging approach for synthesizing higher-order supramolecular polymers with exciting topologies. However, a detailed understanding of growth processes and the synthesis of homochiral superstructures is yet to be demonstrated. Here, we report the non-covalent synthesis of dendritic homochiral superstructures using NIR triimide dyes as building blocks via a secondary nucleation elongation process.

Autologous Fascia Nerve Wrap in a Rodent Primary Epineurial Repair Model and Preliminary Case Series.

Background: Nerve wraps composed of various autologous and bioengineered materials have been used to bolster nerve repair sites. In this study, we describe the novel use of autologous fascia nerve wraps (AFNW) as an adjunct to epineurial repair and evaluate their effect on inflammatory cytokine expression, intraneural collagen deposition and end-organ reinnervation in rats and use of AFNW in a patient case series.

Methods: Lewis rats received sciatic transection with repair either with or without AFNW, sciatic-to-common peroneal nerve transfer with or without AFNW, or sham surgery (n=14/group).

Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies.

Background: Sickle cell disease (SCD) and β-thalassemia patients with elevated gamma globin (HBG1/G2) levels exhibit mild or no symptoms. To recapitulate this natural phenomenon, the most coveted gene therapy approach is to edit the regulatory sequences of HBG1/G2 to reactivate them. By editing more than one regulatory sequence in the HBG promoter, the production of fetal hemoglobin (HbF) can be significantly increased.

Navigating the challenges in radiology training expansion: costs and benefits.

Clinical and interventional radiology services play a vital role in the provision of modern healthcare, but there is a widening gap between the capacity of the imaging workforce and increasing demand. In recent years there has been a programme of training expansion in England supported by tariff level funding from NHS England (Workforce Training and Education Directorate), enhancing long-term radiology workforce sustainability and bringing quality benefits for patients, departments, and trusts. Expansion is a multifaceted and challenging process in the current NHS climate, involving coordination of funding, capacity, and sustained educational quality.

Tofacitinib in Leprosy: A Novel Therapeutic Approach in Chronic Recalcitrant Type II Reactions.

Leprosy is a chronic, infectious, and debilitating disorder that primarily affects the skin and peripheral nerves. The disease course may be complicated by immune-mediated reactions during or after therapy, which may further worsen nerve damage. Type II lepra reaction (T2LR) is a painful inflammatory condition with systemic features, such as fever, tender erythematous nodules, arthritis, neuritis, orchitis, lymphadenitis, and iritis.

Retraction notice to "Modified poly(vinylidene fluoride) nanomembranes for dye removal from water - A review" [Chemosphere 322 (2023) 138152].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).

Retraction notice to "Recent advancements of spinel ferrite based binary nanocomposite photocatalysts in wastewater treatment"[Chemosphere 274 (2021) 129734].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).

Dealing with dichotomies in health care: Case reports.

Dichotomies with respect to medical orientations and public health have been common in the past and even in the present probably orchestrated by the traditional versus modern medical concepts that became eternal arena for disquiet in the healing world of many countries. In public health, the so-called technology tradition was especially dominant which assumed the power of technology and the paternalistic 'managerial mode' regarding disease control programs. Such a 'managerial perversion' has demolished the positivity of primary health care as well as the social determinants framework.

ODD-Net: a hybrid deep learning architecture for image dehazing.

Haze can significantly reduce visibility and contrast of images captured outdoors, necessitating the enhancement of images. This degradation in image quality can adversely affect various applications, including autonomous driving, object detection, and surveillance, where poor visibility may lead to navigation errors and obscure crucial details. Existing dehazing techniques face several challenges: spatial methods tend to be computationally heavy, transform methods often fall short in quality, hybrid methods can be intricate and demanding, and deep learning methods require extensive datasets and computational power.

Risk factors for mortality after 3-column osteotomy.

Purpose: Three-column osteotomies (3COs), such as pedicle subtraction osteotomy (PSO) and vertebral column resection (VCR), are used to surgically correct rigid adult spinal deformity (ASD). While extensive research exists about complications associated with 3COs, there remains a paucity of studies analyzing risk factors for mortality following 3CO. We believe the mortality rate after 3-column osteotomy will be low with specific identifiable demographic or medical risk factors.

Structured Polymers Enable the Sustained Delivery of Glucocorticoids within the Intra-Articular Space.

Intra-articular glucocorticoid injections are effective in controlling inflammation and pain in arthritides but restricted by short duration of action and risk of joint degeneration. Controlled drug release using biocompatible hydrogels offers a unique solution, but limitations of in situ gelation restrict their application. Gellan sheared hydrogels (GSHs) retain the advantages of hydrogels, however their unique microstructures lend themselves to intra-articular application - capable of shear thinning under force but restructuring at rest to enhance residence.

Evaluation of Healing Efficacy of Collagen Matrix and Connective Tissue Graft for Root Coverage Using Doppler Flowmetry: A Case Report.

The epitome of periodontal plastic surgical procedures is to achieve coverage of the denuded root surface and flawless esthetics. Connective tissue graft (CTG) along with coronally advanced flap (CAF) is the most frequent approach, which is considered a gold standard remedy. The procurement of CTG requires a second surgical site morbidity.

Systematic treatment and management of postpartum hypertension using remote patient monitoring.

Objective: To describe postpartum visit attendance and postpartum blood pressure control among patients enrolled in a remote patient monitoring program and compare these outcomes by race.

Study Design: A prospective cohort study of postpartum patients with a diagnosis of hypertensive disorders of pregnancy at the University of Chicago between October 2021 and April 2022. All patients received remote patient monitoring as routine care but consented separately for the use of their data.

Brain networks and intelligence: A graph neural network based approach to resting state fMRI data.

Resting-state functional magnetic resonance imaging (rsfMRI) is a powerful tool for investigating the relationship between brain function and cognitive processes as it allows for the functional organization of the brain to be captured without relying on a specific task or stimuli. In this paper, we present a novel modeling architecture called BrainRGIN for predicting intelligence (fluid, crystallized and total intelligence) using graph neural networks on rsfMRI derived static functional network connectivity matrices. Extending from the existing graph convolution networks, our approach incorporates a clustering-based embedding and graph isomorphism network in the graph convolutional layer to reflect the nature of the brain sub-network organization and efficient network expression, in combination with TopK pooling and attention-based readout functions.

Dehydrogenative Coupling of Alcohols with Hydrazines under Nickel Catalysis.

The development of efficient and robust catalytic systems based on earth-abundant transition metals for fundamentally new transformations is crucial for sustainable chemical synthesis. Herein, an effective and selective Ni-catalyzed dehydrogenative coupling of alcohols with hydrazines with the liberation of ammonia gas is reported. Although several methods were documented for the -alkylation reaction, the present strategy is conceptually novel, and the reaction proceeds through a pathway involving N-N bond cleavage of phenylhydrazine followed by hydrogen autotransfer.

Molecular basis for plasma membrane recruitment of PI4KA by EFR3.

The lipid kinase phosphatidylinositol 4 kinase III α (PI4KIIIα/PI4KA) is a master regulator of the lipid composition and asymmetry of the plasma membrane. PI4KA exists primarily in a heterotrimeric complex with its regulatory proteins TTC7 and FAM126. Fundamental to PI4KA activity is its targeted recruitment to the plasma membrane by the lipidated proteins EFR3A and EFR3B.