Randomized Controlled Study Comparing Efficacy and Toxicity of Weekly vs. 3-Weekly Induction Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma.

Head and Neck Cancer is a major public health problem in India, majority of which are lifestyle related, male predominant requiring dedicated infrastructure and human resource. The 5-year survival is 59% for all stages combined and only 45% in patients with locally advanced inoperable head and neck cancer using current chemoradiation schedules. Chemotherapy agents administered in the induction or concurrent setting comprise of taxanes (Docetaxel, paclitaxel), platinum compounds (Cisplatin, carboplatin) and fluorouracil (TPF).

Role of Intraperitoneal Chemotherapy as the Third-Line Treatment of Epithelial Ovarian Cancer: A Case Report with Literature Review.

The intraperitoneal (IP) administration of antineoplastic agents has been proposed as a method to improve the efficacy of therapy of malignant disease principally confined to the peritoneal cavity especially in carcinoma-ovary. Our patient who had more tumor burden in the peritoneum was refractory to two lines intravenous (IV) chemotherapy who improved on IP administration of platinum and IV nab paclitaxel chemotherapy regime. A 42-year-old lady was diagnosed with stage IV metastatic epithelial ovarian cancer.